The National Cancer Institute (NCI), a component of the Department of Health and Human Services National Institutes of Health, awarded a $101,340 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to the Regents of the University of Michigan. The award will fund research to investigate the role of the MS4A14 protein in regulating macrophage activation and antigen presentation, with the goal of improving immunotherapy response in cancer patients. The research...
This $103,948 Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to the Sloan-Kettering Institute for Cancer Research supports research aimed at elucidating the mechanisms driving T-cell dysfunction within the tumor microenvironment. The research plan includes two main components: Predoctoral research (Aim 1) to investigate how local amino acid availability limits effector function in tumor-infiltrating T-cells, including profiling the...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) will provide $136,412 to the Regents of the University of Michigan to conduct research on defining and interrupting metabolic crosstalk in the glioblastoma (GBM) microenvironment. The primary goals are to: 1) determine mechanistically how metabolite exchange between normal brain cells and GBM cancer cells promotes tumor growth and therapy resistance; 2) investigate the impact of disrupting...
The National Cancer Institute (NCI) awarded a $2,489,032 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research. The 5-year award, effective August 1, 2025, will support three highly integrated research projects focused on determining the roles, regulation, and underlying mechanisms of lipid metabolism in ferroptosis, a form of iron-dependent cell death, and exploring novel cancer therapeutic approaches based on these...
This Project Grant award from the National Cancer Institute (CFDA 93.396, Cancer Biology Research) aims to investigate key transcriptional regulators that drive prostate cancer lineage plasticity, which can lead to more lethal cancer subtypes. The $509,246 award to the Regents of the University of Michigan will fund a 5-year research project to: 1) determine how these transcriptional regulators modulate prostate cancer cell differentiation and hallmarks, 2) understand how the regulators are...
This $509,448 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research by The Leland Stanford Junior University to investigate antigen-presenting cells in lymph nodes and their role in modulating metastatic tumor progression. The key objectives are to: 1) identify the specific antigen-presenting cell populations responsible for promoting tumor-specific regulatory T cell development, and 2) assess therapeutic strategies to reprogram...
This $139,445 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) will fund research by the Regents of the University of Michigan to characterize the role of mesothelial-derived cancer-associated fibroblasts (CAFs) in the pathogenesis of pancreatic ductal adenocarcinoma (PDA). The central hypothesis is that mesothelial cells give rise to a distinct, immunomodulatory population of CAFs that influence the PDA tumor microenvironment. Through in...
This Project Grant award of $153,348, provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) program, supports research by The Trustees of Columbia University in the City of New York to dissect the impact of genomic variants on T cell anti-tumor activity. The project aims to define the mechanisms by which PI3K pathway variants modulate T cell function and evaluate their in vivo efficacy in immunotherapy models for melanoma and leukemia, including in...
This Project Grant award of $147,486 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) supports research at the University of Pittsburgh to investigate the role of altered lipid metabolism in CD8 T cell exhaustion within the tumor microenvironment. The project aims to (1) evaluate the impact of abolishing citrate transport on carbon utilization and effector function of CD8 T cells in the tumor environment, and (2) determine the role of stored lipids in CD8 T cell...
This Project Grant award of $102,324, provided by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), supports research at the Medical University of South Carolina (MUSC) to elucidate the impact of peroxisome biogenesis on adaptive immune responses, particularly within the tumor microenvironment and anti-tumor immunity. The overarching goal is to understand how enhancing peroxisome capacity in T cells can improve their persistence and mitigate exhaustion when exposed to...