This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $102,324.00 to The Medical University of South Carolina (MUSC) to elucidate the impact of peroxisome biogenesis on adaptive immune responses, particularly within the tumor microenvironment and anti-tumor immunity. The overarching goal is to understand how enhancing peroxisome capacity in T cells can improve their persistence and mitigate exhaustion when exposed to the immunosuppressive tumor environment. The funded research will investigate the mechanisms by which peroxisome capacity influences T cell exhaustion, lipid accumulation, and organelle interactions, as well as establish optimal in vivo conditions for generating exhaustion-resistant anti-tumor T cells through adoptive cell transfer experiments. The findings aim to provide novel insights into modulating T cell function and anti-tumor immunity, with potential to improve cancer immunotherapy strategies beyond adoptive cell transfer.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $564 | 5/28/25 | ||
| Not listed | $50.9k | 3/10/25 | ||
| Not listed | $50.9k | 3/10/25 |