The National Institutes of Health's National Cancer Institute awarded $331,085.91 under the Cancer Research Manpower federal grant program (CFDA 93.398) to Brigham & Women's Hospital Inc. on February 1, 2021 for completion by September 30, 2022. The project grant funding will support research investigating the role of cellular senescence in chemotherapy-related cognitive impairment and the contribution of microglia to chemotherapy-induced senescence in the brain. Specifically, the grantee...
The Project Grant award R35CA293978, provided by the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research), supports research to identify the mechanisms driving rapid evolution of cancer genomes. The $942,442 award to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, MA will fund investigations into two catastrophic mutational processes in cancer, chromothripsis and chromoplexy. The research aims to better understand the mechanisms of chromosome fragmentation, DNA...
The National Cancer Institute (NCI), through the Cancer Treatment Research Federal Grant Program (CFDA 93.395), awarded a $1,220,394 project grant to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on September 15, 2024, will fund research to comprehensively characterize the acute and chronic neurotoxicity associated with chimeric antigen receptor (CAR) T-cell therapy for hematologic malignancies. The research aims to investigate the molecular...
This Project Grant award of $223,176 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to define the role of stress granules in cancer initiation. The primary awardee, The Children's Hospital Corporation doing business as Boston Children's Hospital, will leverage a humanized zebrafish melanoma model to investigate how stress granules formed in melanoma precursor cells impact tumor development and progression. The research aims to elucidate the...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $170,640 in funding to the Dana-Farber Cancer Institute, Inc. (DFCI) from July 1, 2025 to June 30, 2027. The grant supports research to investigate the role of histone cleavage in breast cancer, specifically focusing on how the KDM4C histone demethylase drives tumor growth by preventing proteolytic cleavage of the histone H3 N-terminal tail by cathepsin L. The research aims to...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $730,398 to the Sloan-Kettering Institute for Cancer Research to investigate the relationship between leptomeningeal cancer cell growth and inflammatory signaling in the leptomeningeal space. The research aims to mechanistically dissect the CXCL1-CXCR2 signaling axis within the leptomeningeal space, identify cancer cell signals that provoke leptomeningeal CXCL1 generation, and...
This $162,486 Project Grant, awarded by the National Cancer Institute (CFDA Program 93.398 - Cancer Research Manpower), supports research at Case Western Reserve University to study translation regulation and its role in glioblastoma (GBM) stem cell adaptation to hypoxic tumor environments. The research aims to use ribosome profiling and RNA sequencing to elucidate how translational regulation, rather than transcriptional regulation, enables GBM stem cells to survive and proliferate in...
This $588,426 Project Grant award, provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate how transcription factors efficiently locate and bind to specific DNA binding sites within the crowded nucleus of living cells. The project will employ advanced microscopy techniques to precisely track the 3D diffusion, DNA interactions, and target site discrimination of transcription factors involved in...
This $369,868 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the functional role of mitochondrial transfer from nerves to breast cancer cells, and how this process impacts cancer metastasis and the generation of cancer stem cells. The project aims to use innovative lineage-tracing techniques to quantify the contribution of nerve-to-cancer mitochondrial transfer to the breast cancer metastasis cascade, and evaluate...
This federal Project Grant award of $470,567.00 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Beth Israel Deaconess Medical Center, Inc. (BIDMC) aims to identify molecular features that influence response or resistance to PARP-inhibitor treatment in metastatic breast cancer patients without germline BRCA1/2 mutations. The award will fund analysis of pre-treatment tumor DNA and pre- and post-treatment circulating tumor DNA samples from 108 patients enrolled in...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $135,513 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the transcriptional mechanisms underlying chemotherapy-induced cognitive impairment in cancer survivors. The research aims to elucidate the transcriptional regulation governing brain cell disturbances, such as neuronal death and activated microglia, that contribute to this debilitating side effect of cancer treatments. Through comparative brain transcriptomic analysis of mice undergoing chemotherapy and other forms of cognitive impairment, the project will identify key transcription factor regulators that can be manipulated to modify chemotherapy-induced cognitive impairment behaviors. This work is expected to provide new insights into potential therapeutic strategies to ameliorate or reverse this issue affecting cancer survivors. The award period is from Jul 1, 2025 to Jun 30, 2027.