Project Grant K99CA293137

Award Date 7/3/25
Completion Date 6/30/27
Dollars Obligated $113K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This $509,448 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research by The Leland Stanford Junior University to investigate antigen-presenting cells in lymph nodes and their role in modulating metastatic tumor progression. The key objectives are to: 1) identify the specific antigen-presenting cell populations responsible for promoting tumor-specific regulatory T cell development, and 2) assess therapeutic strategies to reprogram...
This Cooperative Agreement award from the National Cancer Institute (NCI), under the Federal Grant Program "Cancer Biology Research" (CFDA 93.396), provides $640,760 to The Leland Stanford Junior University to conduct comprehensive research on the fundamental biological mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) metastasis, organ tropism, and immune evasion. The key products and services to be delivered through this 5-year project include: 1) employing molecular...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $170,655.00 to The Leland Stanford Junior University to develop a new molecular method for mapping protein trafficking between glioblastoma (GBM) cells and other brain cell populations in an in vivo setting. The goal is to better understand the intercellular crosstalk that promotes chemoresistance, invasion, and angiogenesis in GBM, which has an average survival of 15-18...
This federal Project Grant award of $207,900 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program supports research at The Leland Stanford Junior University (Stanford University) to develop a three-cell synthetic immunotherapy system. The goal is to engineer T cells, natural killer (NK) cells, and macrophages to express chimeric antigen...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $931,841 to The Leland Stanford Junior University to develop next-generation immunotherapies for pediatric cancers. The funding will support research to overcome the suppressive tumor microenvironment in pediatric solid tumors, optimize multi-specific CAR T cells, and explore in vivo gene delivery approaches to engineer immune populations without ex vivo manufacturing. This work aims to...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $640,522 to The Leland Stanford Junior University to conduct research aimed at identifying microbial microproteins that can modulate macrophage function and potentially enhance cancer immunotherapy response. The key objectives are to: 1) determine the molecular mechanisms by which two specific microbial microproteins modulate macrophage polarization, 2) screen a large library of candidate...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $119,172 to The Leland Stanford Junior University to conduct research aimed at "Harnessing Multi-Modal and Multi-Omics Data Integration to Decipher Therapeutic Response in Non-Small Cell Lung Cancer." The key objectives are to: (1) Identify clinically relevant spatial cellular architectures contributing to therapeutic response; (2) Develop an image-based digital cytometer to...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $439,644 to The Leland Stanford Junior University to conduct functional studies on human acute myeloid leukemia (AML) stem cells. The key objectives are to: 1) Investigate the relationship between specific genetic mutations and AML stem cell frequency, disease initiation, and disease maintenance by correcting mutations in primary AML cells and AML-induced pluripotent stem cells (iPSCs);...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program, provides $147,486 to the Sloan-Kettering Institute for Cancer Research to support a 3-year training plan in cellular immunology and mechanobiology. The research aims to investigate how microenvironmental stiffness influences immune vulnerability and metastatic site preference in cancer, with the goal of identifying potential biomarkers and novel treatment...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) will provide $135,774 to The Leland Stanford Junior University to conduct research on "Reinvigorating the Overdominant Model of Tumor Suppression." The research aims to systematically measure the overdominant effect of tumor suppressor genes in vivo, investigate the molecular mechanisms of overdominant tumor suppression, and quantify the prevalence of overdominance in lung...

This $113,147 federal Project Grant award was provided by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) to The Leland Stanford Junior University. The grant will fund a 5-year career development program for Dr. Chris McGinnis to prepare him for an independent research career in cancer immunology, focusing on studying tumor-immune interactions during metastasis.

The key objectives are to: 1) Use longitudinal single-cell RNA sequencing to uncover novel mechanisms of pro-metastatic immune remodeling, 2) Benchmark and optimize an ex vivo lung tissue culture high-throughput screening platform to analyze immune perturbation responses in the metastatic niche, and 3) Perform the first anti-metastatic immunotherapy chemical compound screen to identify drugs that inhibit myeloid TLR-NF-kB inflammation in the lung metastatic niche. This research aims to provide critical insights into how tumors use the immune system to spread and identify anti-metastatic immunotherapy candidates.

Generated 8/5/25, 5:38 AM