Project Grant K99CA293134
- This federal Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) provides $153,348 to The Trustees of Columbia University in the City of New York to conduct in-depth mechanistic and in vivo functional studies of single-nucleotide variants (SNVs) that modulate T cell activity for cancer immunotherapies. The research aims to define the mechanisms by which certain PIK3CD SNVs enhance T cell activity and evaluate their impact in murine...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $109,080 to The Trustees of Columbia University in the City of New York to conduct a Phase II, randomized controlled trial evaluating a novel immunotherapeutic approach for treatment-naive metastatic pancreatic adenocarcinoma. The trial will compare a combination regimen of Motixafortide, Cemiplimab, Gemcitabine, and Nab-Paclitaxel against the standard Gemcitabine and Nab-Paclitaxel...
- This $1,480,500 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to elucidate the cell intrinsic and extrinsic mechanisms underlying small cell lung cancer (SCLC) metastasis. The project will develop cutting-edge technologies to establish a comprehensive, spatiotemporally-resolved lineage tracing platform capable of recording the entire course of SCLC metastasis. Specifically, the...
- This $118,722 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to develop a novel immunotherapy for pancreatic cancer. The grant funding will be used by Emory University to engineer CD4+ T cells expressing high levels of the enzyme CD26 and equip them with a chimeric antigen receptor (CAR) targeting mesothelin, a protein expressed on pancreatic tumor cells. The research aims to harness the favorable properties of CD26+ T cells to...
- This federal Project Grant award of $218,055.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research to enhance early detection of pancreatic cancer using GPT-embedded electronic health record (EHR) models. The award, which runs from August 1, 2025 to July 31, 2028, is provided to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division. This research aims to...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Georgetown University for $109,386 provides funding to investigate strategies to increase the co-localization of activated natural killer (NK) cells with tumor cells in pancreatic ductal adenocarcinoma (PDAC). The research aims to explore how inhibiting dipeptidyl peptidases (DPPs) can enhance the efficacy of anti-PD1 immunotherapy by increasing NK cell infiltration and reducing fibrosis in...
- This federal Project Grant award, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research focused on understanding the relationship between inflammatory signaling in the leptomeninges and the growth of leptomeningeal metastatic tumors. The $730,398 award to the Sloan-Kettering Institute for Cancer Research, located in New York, will leverage mouse models and single-cell RNA sequencing to investigate how cancer cell signals induce...
- The federal Project Grant award in the amount of $159,304 was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398). The award was granted to the Dana-Farber Cancer Institute, Inc. (DFCI) to support research on signaling pathways in tumoricidal macrophages in pancreatic cancer. The key objectives of the project include defining the role of deubiquitinases in regulating macrophage surface receptors that govern the recognition and phagocytosis...
- This $156,276 federal Project Grant award was provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) program. The funding supports research aimed at decoding therapeutic tumor antigens and understanding how dendritic cells contribute to anti-tumor T cell immunity, with a focus on pancreatic cancer. Key objectives include comparing tumor immunopeptidomes presented by cancer cells versus dendritic cells, and evaluating the impact of regulatory T cells on...
- This Project Grant award, totaling $102,984, was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) federal grant program. The award supports research by The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, to perform spatio-temporal analyses of the entire brain-metastatic arc, from single-cell interaction with the blood-brain-barrier to fully developed brain metastases. The research will...
This $151,263 federal Project Grant award was provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) program to fund a research project titled "Understanding Paracrine Interactions Induced by Morphogens in PDAC" at The Trustees of Columbia University in the City of New York. The project aims to identify how active morphogen signaling shapes local immunosuppression in the pancreatic tumor microenvironment by studying the interactions between malignant epithelial cells, cancer-associated fibroblasts, myeloid cells, and T cells. The research will combine in vivo and ex vivo studies with a novel pancreatic cancer tumor explant platform to analyze cell-cell communication and leverage this understanding to reactivate anti-tumor immune response. The award has a project period from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $151.3k | 8/11/25 |