This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) will provide $135,774 to The Leland Stanford Junior University to conduct research on "Reinvigorating the Overdominant Model of Tumor Suppression." The research aims to systematically measure the overdominant effect of tumor suppressor genes in vivo, investigate the molecular mechanisms of overdominant tumor suppression, and quantify the prevalence of overdominance in lung...
This $189,163 federal Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) aims to investigate the impact of dietary patterns and physical activity on survival outcomes for patients with renal cell carcinoma (RCC). The research team at Brigham & Women's Hospital, with the University of California, San Francisco as a sub-grantee, will leverage data from three large, prospective cohorts to comprehensively evaluate pre-...
This federal Project Grant award for $166,428 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) will support a new T32 predoctoral training program at Stanford University to prepare the next generation of multi-disciplinary cancer researchers. The program, titled "Genetic and Environmental Basis of Cancer Risk and Disparities (GECARD)," will provide integrative training across fields like epidemiology, biostatistics, genetics, environmental health, and...
This $509,448 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research by The Leland Stanford Junior University to investigate antigen-presenting cells in lymph nodes and their role in modulating metastatic tumor progression. The key objectives are to: 1) identify the specific antigen-presenting cell populations responsible for promoting tumor-specific regulatory T cell development, and 2) assess therapeutic strategies to reprogram...
This Project Grant award of $1,102,957 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Leland Stanford Junior University will fund research to investigate the relationship between cancer and cardiovascular disease. The project aims to: 1) use epidemiological and genetic approaches to map causal links and shared genetic factors between the two disease states; 2) leverage advanced mouse models to prove that cancer can directly promote...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $119,172 to The Leland Stanford Junior University to conduct research aimed at "Harnessing Multi-Modal and Multi-Omics Data Integration to Decipher Therapeutic Response in Non-Small Cell Lung Cancer." The key objectives are to: (1) Identify clinically relevant spatial cellular architectures contributing to therapeutic response; (2) Develop an image-based digital cytometer to...
This $958,434 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by The Leland Stanford Junior University to elucidate the molecular mechanisms of RET kinase regulation in human epidermis and define RET-regulated impacts on the tumor immune microenvironment. The long-term goal is to develop topical selective RET inhibitors for effective therapeutic prevention of cutaneous squamous cell carcinoma (CSCC). The proposed research...
This $135,594 Project Grant award was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) federal grant program. The award aims to develop novel pharmacological approaches to rewire oncogenic gene expression and induce apoptosis in cancer cells, with a focus on aggressive leukemias driven by mixed-lineage leukemia (MLL) gene translocations. The research will involve organic synthesis, pharmacological assays, chromatin mechanism studies, cellular model...
The National Cancer Institute (NCI) awarded a $512,974 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to the Sloan-Kettering Institute for Cancer Research, a non-profit cancer research institution located in New York City. The grant, effective August 13, 2024 through July 31, 2029, will fund research to develop advanced predictive models for non-small cell lung cancer (NSCLC) outcomes using a combination of real-world data sources, including tumor genomic...
The National Cancer Institute (NCI), under the federal Cancer Research Manpower (CFDA 93.398) grant program, awarded a $337,509 project grant to The Leland Stanford Junior University (Stanford University) to conduct high-throughput measurements of RNA-mediated regulation of gene expression and oncogenesis. The project aims to systematically identify functional effector domains within human RNA-binding proteins (RBPs) and investigate how disruptions in RBP function can lead to cancer through...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program, will provide $131,099 to The Leland Stanford Junior University (Stanford University) from July 1, 2025 to June 30, 2027. The award will fund research to investigate the multilevel impacts of obesity-related factors, from molecular to neighborhood levels, on the incidence, aggressiveness, and survival of renal cell carcinoma (RCC). The research aims to unravel the underlying biological mechanisms and identify multilevel prevention strategies to reduce RCC incidence and improve outcomes. The project will apply advanced causal inference methods to elucidate the true impact of body adiposity on RCC survival and explore how pre-diagnosis adiposity influences RCC aggressiveness. Additionally, the research will investigate how neighborhood socioeconomic and built environment characteristics affect RCC across the continuum. This comprehensive research, complemented by a career development plan, will prepare the applicant for an independent research career focused on multilevel cancer prevention.