Project Grant K99AR086336
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $412,610.00 to the Oklahoma Medical Research Foundation (OMRF) to investigate associations between the peripheral blood microbiome and knee osteoarthritis. The key objectives are to determine if baseline peripheral blood bacterial DNA patterns can predict future radiographic and...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $447,783 to the University of Pittsburgh to conduct preclinical research on prosthetic joint infections (PJI) and the use of bacteriophage therapy as a novel treatment. The key objectives are to: 1) evaluate the clonality of S. aureus PJI infections using whole genome sequencing, 2) visualize biofilm...
- This $663,901 Project Grant was awarded on September 1, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports Emory University's research to understand how the gut microbiome and T-cells influence fracture healing. The project aims to investigate how gut bacteria and immune cells, particularly Th17 cells, can be leveraged to improve fracture repair and...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $375,100 to the Regents of the University of Minnesota to conduct a longitudinal study characterizing the role of the mucosal virome and microbiome in juvenile idiopathic arthritis (JIA) flares. The study will enroll 35 children with JIA and 35 healthy siblings, collecting...
- This Project Grant award, valued at $196,460.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The purpose of the award is to test a miniature knee joint system as a new tool to study the role of neuro-immune interactions in osteoarthritis pain. The University of Pittsburgh, the awardee, will use this novel microphysiological system with cartilage,...
- This Project Grant award of $434,682 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of the award is to precisely define the proteolytic events and mechanisms along the timeline of post-traumatic osteoarthritis (PTOA), leveraging a specialized proteomics approach called "degradomics." The award recipient, the Cleveland Clinic...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $167,076 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The University of Iowa. The grant aims to understand the role of resident synovial macrophages in the transition from Lyme arthritis (LA) to antibiotic-refractory Lyme arthritis (ARLA), a condition with significant morbidity and long-term disability. Specifically, the research will: 1)...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $540,974 to Duke University to conduct research on Janus kinase (JAK) signaling in post-traumatic osteoarthritis (PTOA). The research aims to identify the specific JAK molecules that mediate the cartilage degradation and pain associated with PTOA, and to test selective JAK...
- This federal Project Grant award of $646,506 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of dual-action nanoparticle-loaded microparticles for the treatment of osteoarthritis (OA). The research aims to create innovative nanoparticle-based therapeutics that can stimulate the anabolic activity of chondroprogenitors to enhance cartilage...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $378,228 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Washington University located in Missouri, USA. The funding supports a 2-year research project to validate a novel pre-clinical rabbit model for studying the progression of hip pre-osteoarthritis (OA) to full-blown OA. The project aims to confirm the rabbit model accurately mimics the...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded a $104,732 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Oklahoma Medical Research Foundation (OMRF) for the project "Articular Microbiome for Prediction and Potential Therapy of Periprosthetic Joint Infections". The objective is to better understand how the native joint microbiome and phageome may contribute to the risk of subsequent periprosthetic joint infection (PJI) following joint replacement surgery for osteoarthritis. The proposed research involves generating an atlas of microbial DNA patterns in joint tissues and systemic microbiome samples, performing a similar analysis of the virome with a focus on bacteriophages, and leveraging this data to identify phages and phage targets that may be useful for future phage therapy to treat PJI. This research aims to provide new insights into how the joint microbiome and phageome influence the risk of this common and burdensome complication of joint replacement surgery.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $104.7k | 8/5/25 |