Project Grant R21AI190737
- Federal Project Grant Award Summary George Washington University received a $444,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 3, 2026, with a completion date of January 31, 2028. The grant supports research on anthelmintic resistance mechanisms in the hookworm Ancylostoma caninum, with particular focus on cross-class drug resistance selection. The...
- Federal Grant Award Summary George Washington University received a $242,058 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 5, 2025, with completion expected May 31, 2026. The grant funds planning activities for a Phase 2 clinical trial to evaluate the NA-GST-1 hookworm vaccine candidate using a controlled human infection model (CHIM) paradigm. The primary deliverable is...
- Federal Grant Award Summary George Washington University received a $444,920 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025, through August 31, 2030. The award supports pioneering biomedical research investigating the role of endogenous retroviruses (ERVs) in the development of Type 2-dominated allergic inflammation in the lungs induced by house dust...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $777,360 Project Grant to The Washington University under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This award supports research directed at advancing lymphatic filariasis (LF) elimination through parasite genomic epidemiology. The project will deliver comprehensive full-genome analyses of microfilariae (Wuchereria...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University's Office of Sponsored Research Services a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 2, 2026, with a completion date of January 31, 2028. This research initiative focuses on investigating viral infection sensing mechanisms in Caenorhabditis elegans, a model organism used to elucidate fundamental...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,850 to the Whitehead Institute for Biomedical Research under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 20, 2026, for a project extending through January 31, 2031. This Project Grant supports biomedical research investigating how apicomplexan parasites recognize and invade host cells—a critical mechanism for understanding parasitic infections that...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $596,115 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion targeted for July 31, 2030. This five-year award supports investigator-initiated biomedical research examining the long-term impact of persistent parainfluenza virus infection, specifically focusing on how human...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant of $633,218 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 17, 2025, with a completion date of June 30, 2030. This research grant funds a comprehensive investigation into Plasmodium falciparum Niemann-Pick C1-Related Protein 1 (PfNCR1), a cholesterol transporter located at the interface between the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $388,004 Project Grant to The Washington University (Office of Sponsored Research Services) on July 16, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports investigator-initiated research addressing heme homeostasis mechanisms in the malaria parasite Plasmodium falciparum, with performance conducted in St. Louis, Missouri through January...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $773,053 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 6, 2025, with a completion date of May 31, 2030. This research project focuses on elucidating the biosynthesis of beta-1,6-glucan in the cell wall of Cryptococcus neoformans, a fungal pathogen responsible for approximately 150,000 deaths annually,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded George Washington University a $444,125 Project Grant (CFDA 93.855 – Allergy and Infectious Diseases Research) effective February 3, 2026, through January 31, 2028, to conduct research on the genetic determinants of host immunity-mediated resistance to helminth infection. The project leverages a panel of genetically diverse Collaborative Cross (CC) mouse strains to identify and validate novel genes that modulate host-parasite interactions during Ascaris infection, focusing specifically on the lung stage of parasitic infection. By integrating phenotypic screening with advanced genetic mapping techniques, the research aims to uncover how human genetic variations contribute to differential susceptibility and resistance to helminth infections, which affect over 1.5 billion people worldwide and are characterized by Type 2 immune responses marked by production of interleukin-4, interleukin-5, and interleukin-13. The research deliverables include identification of key genetic determinants driving distinct immunological responses during helminth infection, validation of candidate genes through murine infection models, and characterization of tissue-specific immune responses in the pulmonary system. These findings are intended to advance scientific understanding of host-parasite interactions and may inform future therapeutic interventions for the substantial global public health burden posed by helminth infections.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.1k | 2/3/26 |