Project Grant K99AG090628
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital (MGH) a Project Grant of $629,562 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating the role of mechanoaging in intestinal homeostasis deterioration with age. The research project, scheduled for completion by July 31, 2030, addresses a critical knowledge gap regarding how mechanical stiffening of the intestine contributes to...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
- Federal Grant Award Summary The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School $460,625 on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct a two-year research project concluding April 30, 2027. This project grant supports biomedical research investigating the role of Mixed Lineage Kinase Domain Like Pseudokinase (MLKL) in platelet-mediated immune responses during respiratory viral infections in older adults. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital $1,875,196 under the Aging Research program (CFDA 93.866) on August 5, 2025, for a project extending through July 31, 2029. This project grant supports comprehensive genomic research investigating the genetic basis of exceptional longevity and resilience to aging-related diseases by studying the ocean quahog (Arctica islandica), the world's longest-lived animal capable of surviving over...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $636,342 Project Grant effective August 1, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This research initiative supports multiscale modeling and empirical studies examining normal and pathological brain aging, with particular focus on myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex. The project employs rhesus...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant of $132,705.00 (awarded June 15, 2025; completion date May 31, 2027) under the Aging Research program (CFDA 93.866) to investigate metabolic vulnerabilities in hematopoietic stem and progenitor cells (HSPCs) during aging. The research addresses the decline in blood system function with age, specifically examining how metabolic heterogeneity among HSPCs contributes to...
- Federal Project Grant Award Summary The National Institute on Aging awarded President and Fellows of Harvard College (Harvard Medical School) $478,624 under the Aging Research program (CFDA 93.866) for a two-year project grant extending from August 15, 2025 to July 31, 2027. The project develops cross-platform fluorescent reporter technologies to measure 26S proteasome and VCP (valosin-containing protein) activities in biological systems relevant to aging and neurodegenerative disease...
The National Institute on Aging (NIA) awarded Massachusetts General Hospital a Project Grant of $134,726 on February 18, 2026, under the Aging Research program (CFDA 93.866) to support research investigating the biological mechanisms of proteomic aging and frailty prediction. The project, scheduled for completion by January 31, 2028, will deliver three primary research products: (1) identification of causal aging proteins associated with chronic diseases through Mendelian randomization and colocalization analysis using genetic data from over 500,000 individuals across four large cohorts (UK Biobank, Multi-Ethnic Study of Atherosclerosis, FinnGen, and All of Us); (2) mapping of the epigenetic and transcriptional regulation of these identified proteins; and (3) development of a proteomic prediction model to identify patients at high future risk of frailty before disease onset to enable early preventative interventions. This research addresses a critical gap in aging science by providing scalable, transferable clinical screening tools to predict frailty risk and identifying potential therapeutic targets through large-scale proteomic analysis. The work will integrate genetic, multi-omic, and clinical data from a combined study population of 70,225 individuals across participating biobanks and research networks, directly supporting the NIA's mission to advance understanding of aging processes and improve prevention and treatment strategies for age-related diseases and conditions affecting older adults.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $134.7k | 2/18/26 |