Project Grant K99AG088064
- This $2,044,038 federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research into the mechanisms driving anxiety in Alzheimer's disease (AD). The project, led by New York University School of Medicine, aims to investigate the role of the thalamo-hippocampal-prefrontal circuit in AD-related anxiety. The research will use mouse models of AD to elucidate the functional synaptic architecture, in vivo neural activity, and causal impact of...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $300,892 project grant to Duke University to conduct research on high-resolution diffusion imaging of brain connectivity in healthy aging and Alzheimer's disease. The project aims to examine how white matter disconnection affects brain function in both healthy aging and Alzheimer's disease, leveraging a high-resolution multi-shot diffusion-weighted imaging (DWI) protocol. The research...
- The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
- This federal Project Grant award of $815,215 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting a multi-modal imaging study to understand sex-based differences in brain circuitry and Alzheimer's disease (AD) pathology. The research, led by Yale University, has two key aims: 1) leveraging a new prospective cohort to test the impact of sex and sex-based factors like reproductive period and APOE genotype on functional brain networks and tau progression in...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $127,386 in funding to Yale University for a longitudinal study on the impact of stress and aging on synaptic changes using in vivo positron emission tomography (PET) imaging in animal models. The 5-year research project aims to investigate how chronic stress may accelerate age-related brain changes and contribute to cognitive decline. The research will involve comprehensive training in...
- The U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Aging has awarded a $1,711,908 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to conduct research on the association between depressive symptoms and cortico-limbic tau, cerebral blood flow, neurodegeneration, and longitudinal cognitive decline in individuals with mild cognitive impairment. The project will seek to clarify the...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $132,786 project grant to Yale University to investigate the role of cortico-limbic circuit dysfunction in manifesting anxiety in individuals with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The key objectives of the 2-year grant are to: 1) characterize the functional connectivities of the emotion regulation circuit during healthy aging, 2) identify connectivity markers that distinguish Alzheimer's disease from healthy controls in individuals with MCI, and 3) investigate cortico-limbic circuit dysfunction in emotion processing, regulation, and memory in individuals with SCD compared to healthy controls. The grant will leverage neuroimaging data from the Human Connectome Project-Aging (HCP-A) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies to address these aims.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/10/25 | ||
| Not listed | $132.8k | 8/14/25 |