Project Grant K99AA032329
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
- This $587,361 federal Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) to the University of Colorado-Denver will fund a 5-year research project to investigate the relationship between pain, negative affect, and alcohol use. The project will combine laboratory-based pain induction and ecological momentary assessment (daily text-message surveys) to examine pathways from pain to alcohol use, as well as factors like pain...
- This $232,316 Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research to investigate the role of a novel dynorphinergic circuit in the central amygdala and its connection to the nucleus accumbens. The research aims to understand how this circuit is modulated by chronic pain and fentanyl abstinence, and how it contributes to binge-like alcohol drinking behavior, pain-related cognitive effects, and reinstatement of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- This federal Project Grant award of $123,045.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports research to investigate interactions between the alcohol and cannabinoid systems in the context of pain and alcohol use disorder (AUD). The project aims to examine the potential analgesic effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, on pain...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $571,673 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Mississippi Medical Center (UMMC). The funding supports research to investigate the combined behavioral effects of opioids and alcohol, and the potential role of a genetic variant of the mu opioid receptor (OPRM1 A118G) in influencing individual vulnerability to opioid-alcohol use and abuse. The research project will use rhesus...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $136,236 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Washington on January 25, 2025. The grant project aims to investigate the synergistic effects of chronic alcohol use and pathological tau expression in a preclinical model, in order to better understand the neurodegeneration processes underlying Alzheimer's disease and related dementias (ADRD). Specifically, the research will...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $3,168,729 to New York University to conduct a collaborative research project titled "A Translational Approach for Novel Precision Medicine Models." The project aims to identify novel molecular targets and mechanisms of treatment responses in alcohol use disorder (AUD) based on the role of mitochondrial metabolism and epigenetic...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a Project Grant of $180,939 to Yale University on September 1, 2025. The grant funding will support a study examining neurobiological threat reactivity as a potential biomarker for the comorbidity of chronic pain and alcohol use disorder (AUD). The project aims to use functional neuroimaging to investigate how the anterior insular cortex circuit function correlates with the severity of chronic pain and AUD symptoms in affected individuals. The research will combine imaging data with longitudinal tracking of daily pain and alcohol use behaviors. This study seeks to fill a critical knowledge gap by directly testing the hypothesis that a maladaptive response to uncertain threat may be a shared pathway linking chronic pain and AUD, with the goal of informing the development of more effective mechanism-driven interventions for this comorbid condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $180.9k | 8/26/25 |