Project Grant R01AA031505
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $248,844 to the University of North Carolina at Chapel Hill (UNC-CH) for research on the use of blood-based RNA biomarkers to diagnose and monitor Alcohol Use Disorder (AUD). The research aims to determine whether blood gene expression profiles can serve as a non-invasive proxy for brain tissue to aid in personalized medicine approaches...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This federal Project Grant award of $423,313, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), aims to develop an AI-driven platform for identifying potential therapeutic candidates for Alcohol Use Disorder (AUD). The award to Biosymetrics Inc., based in Huntington, NY, will leverage the company's existing AI-based zebrafish behavioral screening technology and AUD-specific experimental findings to create a commercial...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...
- This Project Grant award, totaling $560,108.00 and spanning September 15, 2025 to August 31, 2030, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the project is to investigate the neurocognitive mechanisms that promote resilience to alcohol use disorder (AUD) in individuals with a family history of AUD. Specifically, the research will examine how attentional abilities may...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, supports a $559,180 research project to investigate neurobiological factors underlying Alcohol Use Disorder (AUD) with and without comorbid cigarette smoking. The project aims to identify AUD-associated differences in DNA methylation and RNA expression in the nucleus accumbens and dorsolateral prefrontal cortex, key brain regions...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate the role of cell-type specific gene regulatory networks in alcohol dependence and escalation. The $149,875 award to the University of Texas at Austin will fund a research project with the following key objectives: Assess the impact of genetically rescuing an astrocytic gene co-expression module upregulated in...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $734,283 to Mayo Clinic to explore the relationships between circulating neuroactive steroid levels and alcohol use disorder (AUD), as well as AUD-related phenotypes. The project aims to measure the serum levels of allopregnanolone, its precursors, and isomers using gas chromatography coupled with mass spectrometry. This neuroactive...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $3,168,729 to New York University to conduct a collaborative research project titled "A Translational Approach for Novel Precision Medicine Models." The project aims to identify novel molecular targets and mechanisms of treatment responses in alcohol use disorder (AUD) based on the role of mitochondrial metabolism and epigenetic regulation. Key objectives include determining the impact of mitochondrial metabolism and associated epigenetic changes on AUD treatment responses, as well as mapping the topographical and cellular specificity of these changes. The research will leverage preclinical and clinical findings to advance the understanding of AUD pathophysiology and develop potential new precision medicine approaches. The award period runs from September 10, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/16/25 | ||
| Not listed | $3.2m | 9/10/25 |