Project Grant K25HL175222
- This federal Project Grant award of $805,921 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to integrate multi-trait, multi-ancestry, and multi-omic data from massive global biobanks to decipher the genetic mechanisms underlying respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. The award, with a performance period from September 2025 to June 2030, will leverage data from over 2 million participants,...
- This Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund the development of novel computational methods to investigate the role of DNA methylation in the progression of Chronic Obstructive Pulmonary Disease (COPD). The $1,470,578 award, spanning from January 1, 2025 to December 31, 2028, will enable researchers at the University of Florida to assemble and analyze multi-omic data from large COPD...
- This Project Grant award of $800,679.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support the University of Virginia's research to interrogate the pathogenesis of chronic obstructive pulmonary disease (COPD) using metabolomics and genomics data. The objective is to expand the PredixCan method to incorporate metabolomics data, creating a new tool called MetaBoxCan, in order to extract more comprehensive mechanistic information from...
- This federal Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports a research project at Brigham & Women's Hospital Inc. to better understand changes in the pulmonary vasculature and their relationship to lung parenchyma using advanced CT imaging in patients with pulmonary hypertension and chronic obstructive pulmonary disease (COPD). The $812,189 award, with a project period from May 1, 2025 to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $708,063 in funding to the University of Virginia for a research project titled "Post-Transcriptional Regulatory Networks in Chronic Obstructive Pulmonary Disease". The goal of the 5-year project is to generate RNA-binding protein (RBP) regulatory networks, identify COPD-specific changes, and characterize the functional consequences of the network changes....
- This $131,783 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a study to develop and implement a protocol for biospecimen collections before and after bronchoscopic lung volume reduction (BLVR) procedures in COPD patients. The goal is to identify blood and bronchoalveolar lavage fluid biomarkers associated with COPD phenotypes...
- This Project Grant award of $258,516 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund research to better understand the role of mitochondrial-derived peptides (MDPs) in the development of chronic obstructive pulmonary disease (COPD). The University of Pittsburgh will utilize the NHLBI BIOLINCC repository to analyze plasma and lung tissue samples to characterize changes in MDPs across COPD disease severity. They will combine...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This federal Project Grant award of $123,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the Hedgehog signaling pathway in regulating progenitor cell differentiation during lung development and its potential contribution to lung diseases like COPD and IPF. The project will analyze existing single-cell data from mouse and human lungs to: 1) decipher the temporal control of Hedgehog signaling in regulating...
- This $116,625 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will characterize clinically relevant phenotypes related to osteoporosis and sarcopenia in chronic obstructive pulmonary disease (COPD). The project will develop automated methods to derive static metrics of spine, vertebrae, and pectoral muscles, as well as dynamic metrics of lung diaphragmatic surface deformation, from chest CT scans. It will then use...
This federal Project Grant award of $140,403 from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development and application of new multi-omic analytical methods to elucidate the shared and divergent biology underlying chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). The 5-year research project, conducted by the Harvard T.H. Chan School of Public Health, aims to 1) map conditional dependence between genotype, gene expression, and DNA methylation, 2) identify a panel of genes involved in the differential etiology of COPD and IPF, and 3) map lung disease trajectories using multi-omic similarity networks. This work is expected to provide critical insights into the molecular mechanisms underlying these progressive lung diseases and their divergent outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $140.4k | 8/1/25 |