This federal Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, provides $179,002 to the Mclean Hospital Corporation to conduct a multilevel characterization of sensory cortical disinhibition in post-traumatic intrusions. The project aims to link lower levels of inhibitory neural activity and imbalances in excitatory/inhibitory neurotransmitter systems to perturbations in intrinsic functional organization of...
This $2,376,102 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research to fine-map and characterize the mechanisms underlying genetic risk factors for post-traumatic stress disorder (PTSD). The primary awardee, The McLean Hospital Corporation, is partnering with sub-awardees at SUNY Downstate Health Sciences University and the University of California, San Diego to: 1) identify causal variants...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $211,248 to the University of California, Los Angeles (UCLA) to conduct research on the neural mechanisms underlying fear and anxiety responses in the human hippocampal-amygdala circuit. The project aims to: 1) elucidate how the hippocampus and amygdala interact to govern the acquisition, extinction, and renewal of fear and anxiety...
The University of Chicago was awarded a $617,737 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant will fund a research project investigating the role of the thalamic nucleus reuniens in suppressing and extinguishing contextual fear memories, which is critical for understanding and treating post-traumatic stress disorder (PTSD). Through this project, the researchers will use advanced techniques like 2-photon...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,072,702 to the University of Vermont & State Agricultural College to investigate the neural substrates underlying the encoding and retrieval of higher-order fear memories. The research aims to use chemogenetic and electrophysiological recording methods in freely moving rats to study how cortical networks process and represent these types of...
This federal Project Grant award, R01MH134873, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to study the molecular and cellular mechanisms by which dopaminergic neurons in the zona incerta (A13 cells) influence extinction learning. The $732,367 award to Children's Hospital Los Angeles will fund a 5-year research project to determine how these dopaminergic neurons contribute to the deficits in extinction learning...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, will support research into the neurocircuitry underlying motivated reward-seeking behavior as a coping mechanism for stress. The $606,029 award, effective August 1, 2024 through July 31, 2025, will be administered by the University of Massachusetts Medical School. The key objectives are to investigate how sub-populations of neurons in the medial...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $1,932,991 to conduct research on the neural computations underlying learning, decision-making, and memory. The goal is to characterize core computations of value, uncertainty, and prediction error across cognitive processes and domains, and to identify associations between these computations and symptoms of anxiety and stress-related disorders. The research...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants aims to identify sleep-related risk factors for post-traumatic stress disorder (PTSD) and their underlying mechanisms. The $435,426 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will leverage data from the AURORA study to: 1) determine which individuals have a susceptibility to acute sleep disturbances...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a $177,833 research study at Wayne State University to investigate the intergenerational impact of maternal childhood trauma on children's fear neurobiology and internalizing psychopathology risk. The 1-year study will enroll 120 Black American mother-child dyads to assess the relationship between maternal trauma history, PTSD symptoms, children's...