This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $194,899 to the Icahn School of Medicine at Mount Sinai to conduct research on the neurocognitive mechanisms underlying compulsivity, with a focus on obsessive-compulsive disorder (OCD). The goal of the 5-year project is to use computational modeling and EEG analysis to better understand how deficits in the integration of goal-directed...
This federal Project Grant award of $809,312, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to characterize circadian function and identify circadian dysfunction among children with Attention-Deficit/Hyperactivity Disorder (ADHD). The primary objectives are to: 1) Assess individual differences in circadian function and sleep profiles using laboratory-based dim light melatonin onset (DLMO) assessment and wearable...
The National Institute of Mental Health (NIMH) awarded a $1,330,840 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Southern California (USC) to conduct the MEGA-OCD initiative. This is the largest and most highly powered neuroimaging investigation of obsessive-compulsive disorder (OCD) to date, drawing on diverse worldwide data to rigorously address pressing questions about OCD with unprecedented statistical power. The key objectives are to: 1)...
The National Institute of Mental Health (NIMH) awarded a 5-year, $721,862 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The University of Kentucky Research Foundation to characterize and modulate functional connectivity and fear extinction abnormalities in obsessive-compulsive disorder (OCD). The project aims to examine if OCD is associated with deficits in inhibitory safety learning and fear extinction learning, and to test if frontopolar transcranial direct current stimulation...
This federal Project Grant award of $199,739, provided by the National Institute on Disability, Independent Living, and Rehabilitation Research (CFDA 93.433), will support research to help adults with obsessive compulsive disorder (OCD) succeed at work through the Individual Placement and Support (IPS) model of supported employment. The award, which runs from September 1, 2024 to August 31, 2027, will be implemented by the Research Foundation for Mental Hygiene, Inc. (RFMH), doing business as...
The National Institute of Mental Health (NIMH) awarded a $2,809,928 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to conduct a multi-site, double-blind, randomized-controlled efficacy trial of a transdiagnostic intervention for sleep and circadian dysfunction to improve depression symptoms in older adults with high suicide risk. The study aims to confirm the target engagement and efficacy of this intervention, as well as develop an algorithm to...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund a mechanistic clinical trial to evaluate the role of the metabotropic glutamate receptor subtype 5 (mGluR5) in the antidepressant mechanism of cognitive behavioral therapy for insomnia (CBT-I) in adults with major depressive disorder. The $808,417 award, effective May 1, 2025 through March 31, 2030, will be provided to the Research Foundation...
This Project Grant award of $507,427 from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, supports research at the University of South Carolina to investigate the neurobiological effects of altered light environments on somatostatin neuronal circuits in the medial amygdala during pubertal development. The goal is to characterize how somatostatin neurons in this brain region...
This $793,161 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a 5-year experimental study to investigate the relationship between nocturnal wakefulness and suicide risk factors. The University of Arizona, the prime awardee, will recruit 90 adults with recent suicidal ideation to participate in laboratory-based assessments of cognitive processes and affect at different times of day, as well as...
This federal Project Grant award of $826,902 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the dynamic relationships of physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The award will fund a micro-longitudinal study leveraging wearable technology to objectively track daily...