Project Grant K23HL181397
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance precision medicine for Acute Respiratory Distress Syndrome (ARDS) and sepsis. The $2,295,984 award to the University of California, San Francisco (UCSF) will fund research to address critical unanswered questions about the distinct molecular phenotypes of ARDS and sepsis, and how to optimize real-time phenotyping and integrate analyses of phenotype-specific...
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- This Project Grant award of $153,099.00 from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) is funding research to use target trial emulation and g-methods for causal inference from observational data to address gaps in knowledge about the care of patients with acute respiratory distress syndrome (ARDS), with a focus on evaluating dynamic treatment regimes for steroid initiation, duration, and dosing. The research will utilize data...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $816,119 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Oregon Health & Science University (OHSU). The overall objective of this 4-year project is to conduct an in-depth analysis of pediatric prehospital emergency ventilation and identify the ventilation strategy associated with the best patient outcomes. The project will leverage data collected through the NHLBI-funded PEDI-PART trial, which...
- This Project Grant award of $807,067.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to pioneer the quantitative documentation of human respiratory kinematic profiles. The study aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. Building on a recent innovation called ARK...
- This $247,500 project grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to develop a non-invasive model for early detection of pulmonary vascular dysfunction (PVD) in patients with acute respiratory distress syndrome (ARDS). The research aims to leverage proteomic analysis of plasma samples from ARDS patient cohorts to derive and validate a classifier that can accurately identify PVD, a high-risk ARDS subgroup with...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $748,970 in funding to The Trustees of the University of Pennsylvania to conduct research aimed at better understanding the implementation of evidence-based treatments for mechanically ventilated patients in intensive care units (ICUs). The key research objectives are to: 1) quantify the penetration over time of four evidence-based treatments (sedation...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $737,815 to The Washington University in St. Louis to develop and validate an automated electronic health record (EHR)-embedded system that can classify molecular phenotypes of acute respiratory distress syndrome (ARDS) and sepsis at the bedside. The primary objective is to translate advanced research on ARDS and sepsis heterogeneity into clinical...
- This federal Project Grant award of $1,479,335.00 from the National Heart Lung and Blood Institute under CFDA 93.837 Cardiovascular Diseases Research aims to leverage observational data and advanced machine learning methods to address gaps in understanding and personalizing treatment for Acute Respiratory Distress Syndrome (ARDS). The key products and services to be delivered include: Developing improved methods for ARDS phenotyping using dynamic clinical data to better understand prognosis...
This Project Grant award of $178,846.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize ventilator management for patients with acute respiratory distress syndrome (ARDS) who require extracorporeal membrane oxygenation (ECMO) support. The primary goal is to determine if personalized positive end-expiratory pressure (PEEP) settings guided by esophageal manometry can reduce ventilator-induced lung injury (VILI), as measured by biomarkers of inflammation, compared to standard PEEP guidelines. The study will prospectively randomize 62 ARDS patients on ECMO to the two PEEP approaches and assess physiological outcomes. The findings are expected to provide insights relevant for ARDS management beyond just the ECMO population. The award was made to the University of California, San Diego, which has extensive experience conducting cardiovascular and critical care research for federal agencies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $178.8k | 7/25/25 |