This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $117,000 to conduct secondary analysis of 3D echocardiography images to compute 3D surface strain of the right ventricle. The goal is to develop computational methods that enable routine spatial and temporal examination of 3D strains using machine learning, and compare these novel 3D strain parameters to disease outcomes in...
This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to understand the biomechanical mechanisms underlying right ventricular (RV) dysfunction and ventricular-arterial uncoupling in pulmonary hypertension. The $642,045 award to the Texas A&M Engineering Experiment Station (Tees) aims to: 1) determine how passive remodeling of the RV free wall competes with...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $477,290 to Mayo Clinic to investigate the underlying behavioral mechanisms that impact a home-based pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the associations between patterns of physical activity, sedentary behavior, sleep, and cognitive...
This federal Project Grant award of $233,250 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a research study at the University of Iowa to characterize changes in airway and chest wall deformation between inspiratory and expiratory lung volumes in patients with chronic obstructive pulmonary disease (COPD). The study will leverage established datasets from nationwide longitudinal lung studies to develop normative models of airway and...
This $102,932 federal Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify clinically accessible metrics that can serve as surrogates for right ventricular-pulmonary arterial (RV-PA) coupling and indicators of RV adaptation in pulmonary arterial hypertension (PAH). The proposed research aims to: 1) develop a multivariable model to identify clinically available metrics as...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $812,189 to Brigham & Women's Hospital Inc. for a research project titled "Clinical CT Imaging for Screening and Subtyping of Pulmonary Hypertension in COPD". The project aims to leverage CT imaging data from several NIH-funded cohorts, including PVDOMICS, COPDGENE, and CARDIA, to develop non-invasive methods for diagnosing...
This federal Project Grant award of $725,088 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to optimize the effectiveness and implementation of COPD self-management treatment. The primary goal is to conduct a factorial optimization trial among 448 individuals with COPD to evaluate the impacts of treatment components including self-management education, physical activity, and inhaler training on respiratory-related hospitalizations and...
The University of Wyoming received a $323,277 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research to identify mechanisms of right ventricular (RV) dysfunction in type 2 diabetes. The project aims to 1) determine how increased fatty acid uptake contributes to RV lipotoxicity and dysfunction, and 2) identify mechanisms of impaired reactive oxygen species signaling in the...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $708,063 to the University of Virginia to conduct research on post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) develop a method to identify RNA-binding protein (RBP) to isoform regulatory networks in COPD, 2) functionally characterize COPD-associated RBP subnetworks, and 3) use long-read...
This $245,626 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) aims to validate lipidomic signatures related to right ventricular and pulmonary vascular dysfunction in patients with or at risk for pulmonary vascular disease. The research, conducted by The Johns Hopkins University, seeks to: 1) validate lipidomic signatures in the larger, multi-center PVDOMICS cohort and investigate...