Project Grant K23HD113836
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $179,475 to The Children's Hospital of Philadelphia (CHOP) to conduct research on pediatric sepsis. The key objectives of the project are to define and validate a molecular subphenotyping model that can predict the severity of sepsis in children, and to test the reversibility of immune dysregulation through targeting...
- The federal Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to obtain new insights into gut dysbiosis and inflammatory signaling cascades related to metabolic disturbances in youth with perinatally acquired HIV (YPHIV) in sub-Saharan Africa. The $265,369 award to the Ann & Robert H Lurie Children's Hospital of Chicago...
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $418,750.00 to The Feinstein Institutes for Medical Research to conduct research on T cell receptor-mediated T cell activation in neonatal and pediatric sepsis. The goal is to gain insight into how T cell memory influences sepsis-associated organ dysfunction, by comparing responses between human neonates with sepsis and...
- This Project Grant award of $186,221 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to develop personalized therapies for pediatric sepsis. The primary objectives are to augment sepsis phenotypes through the integration of high-frequency physiologic data with electronic health record data, and to retrospectively identify sepsis subtypes that may respond differently to various...
- This $293,550 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding research to investigate the effect of inherited maternal cells on BCG-specific T cell responses in HIV-exposed and unexposed infants. The award supports a study hypothesizing that reduced transmission of maternal microchimerism in utero may be a mechanism...
- This Project Grant award, in the amount of $187,410, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will support Dr. Hilary Faust, an early-career physician-scientist, in developing novel approaches to identify and target sepsis-associated endothelial dysfunction. The funding will enable Dr. Faust to master advanced techniques for modeling human sepsis-associated endothelial injury...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $588,566 to the University of Maryland, Baltimore to conduct a cross-disciplinary study on the long-term neurodevelopmental and school readiness impacts of in-utero HIV exposure on children in Sub-Saharan Africa. The research aims to establish a core team of investigators who can...
- This federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to enhance mortality surveillance and improve understanding of disease burden among children under 5 in low and middle-income countries. The $115,585 award supports a two-year project led by Dr. Sandipan Pramanik at The Johns Hopkins University to develop a country-specific modeling...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research led by Dr. Carolyn McGann of the Children's Hospital of Philadelphia (CHOP) to define transmission pathways for sepsis-causing pathogens in low-resource settings using microbiome methods and spatial epidemiology. The $155,185 award, effective from September 1, 2025 to August 31, 2030, will enable Dr. McGann to acquire the mentorship, training, and research experience needed to transition to becoming an independent global health scientist focused on neonatal sepsis prevention. The research plan involves leveraging an existing cohort and biobank to evaluate risk factors for neonatal colonization with sepsis-causing pathogens, with the goal of interrupting transmission pathways in low- and middle-income countries.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.2k | 8/26/25 |