The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant to Brooklyn Innoseq Inc. (doing business as MaMome) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $296,351 grant aims to develop and validate a non-invasive microbiome-based diagnostic tool for the early detection of gestational diabetes mellitus (GDM). Specifically, the grantee will prospectively enroll 250 pregnant women, collect stool samples, and use...
This Project Grant award, valued at $421,067.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award will fund research conducted by the University of North Carolina at Chapel Hill to investigate how in-utero exposures to the pregestational diabetic milieu affect kidney development using kidney organoid models. Specifically, the research aims to study the effects on...
The National Institute of Child Health and Human Development (NICHD) awarded a $829,637 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Alabama at Birmingham on Sep 13, 2024 to conduct the "Continuous Glucose Monitoring for Management of Type 2 Diabetes in Pregnancy (CGM2 Trial)". The overarching goal is to improve maternal and neonatal outcomes and achieve health equity for pregnant individuals with type 2 diabetes. The project...
The National Institute of Child Health and Human Development (NICHD) awarded a $148,568 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Colorado-Denver. The grant, effective February 1, 2025 through July 31, 2026, supports research to identify the mechanisms by which fetal glucagon regulates placental nutrient delivery and uterine blood flow. Key objectives include establishing how fetal glucagon inhibits placental...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $154,500 to Howard University to investigate the roles of placental mitochondria in the vicious cycle of diabetes and pregnancy. The key objectives are to: 1) Confirm the impaired placental mitophagy (mitochondrial autophagy) mediated by the protein BNIP3 in gestational diabetes mellitus...
This $153,252 Project Grant award was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at Duke University to develop new strategies for identifying individuals at high risk of genetic diseases, with the goal of enabling earlier diagnosis and treatment. Specifically, the grant has two key objectives: 1) Re-evaluating guidelines for universal...
This $1,007,897 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a prospective cohort study of 350 pregnant American Samoan women to investigate the impact of the CREBRF genetic variant on the risk of gestational diabetes and progression to postpartum type 2 diabetes. The study aims to comprehensively evaluate glucose...
This federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, is focused on developing non-invasive liquid biopsy screening methods for early detection and prediction of preterm birth, preeclampsia, and intrauterine growth restriction. The $717,871 grant was awarded on Aug 13, 2024 to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA. The research aims...
This federal Project Grant award of $502,710.55 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to identify the molecular mechanisms linking lactation to metabolism. The research will utilize single-cell RNA sequencing of human milk-derived cells as "liquid breast biopsies" to understand the effects of maternal gestational diabetes on mammary epithelial cell (MEC)...
The National Institute of General Medical Sciences (NIGMS) awarded a $123,221 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Alabama at Birmingham (UAB) to identify gestational-induced changes in islet macrophages as a potential target for beta-cell expansion. The key objectives of this 2-year research project are to: 1) characterize the macrophage population within the islet throughout pregnancy, and 2) establish the requirement of macrophages for...