The federal Project Grant award R34AT012767, provided by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund feasibility and acceptability testing of an integrated intervention combining digital cognitive behavioral therapy for insomnia (dCBT-I) and passive body heating (PBH) for the treatment of insomnia disorder. The $737,480 award will support two studies: (1) an iterative...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a $121,424 study examining the relationship between early sleep disruption, functional brain networks, and developmental trajectories in infancy. The study will leverage data from two longitudinal NIH-funded projects - the Infant Brain Imaging Study (IBIS) and the Healthy Brain and Child Development (HBCD) Study - to (1) investigate how...
The U.S. National Institute on Aging (NIA) awarded a $134,000 project grant under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct a pilot study on a digital cognitive behavioral therapy for insomnia (DCBT-I) intervention for older adults undergoing orthopedic surgery. The goal is to evaluate the feasibility and efficacy of this abbreviated DCBT-I protocol in improving sleep and cognitive resilience...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $383,400 to Dr. Minjee Kim at Northwestern University to investigate the role of sleep disturbance as a potentially modifiable determinant of cognitive impairment and Alzheimer's disease. The award will fund Dr. Kim's research to: 1) examine associations between sleep disturbance, cognitive function, self-care capacity, and health status in middle-aged adults; 2) develop sleep disturbance...
This Project Grant award of $633,671 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports research on the safety of prescription sleep medications in children, adolescents, and young adults with Attention Deficit Hyperactivity Disorder (ADHD). The key objectives are to: 1) Evaluate nationwide patterns of prescription sleep medication use and dose-escalation in youth with ADHD; 2) Determine the extent to which these...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and evaluate a culturally adapted sleep intervention program for older Korean immigrants with limited English proficiency. The $433,125 award will fund a 2-year pilot study, starting on February 1, 2025, to refine an existing cognitive behavioral therapy for insomnia (CBTI) program with input from stakeholders and Korean immigrants, and then conduct a randomized clinical trial to assess...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,602,357 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to KDH Research & Communication, Inc., a woman-owned small business located in Atlanta, GA. The grant funds the development and evaluation of the "Personalized Approach to Habits-Sleep" (PATH-S) mobile app, which aims to improve sleep duration and asthma symptoms for Black teenagers aged 14-17 with asthma. The PATH-S app will...
This Project Grant award from the National Institute of Nursing Research (NINR), under CFDA Program 93.361 Nursing Research, provides $114,843 to the University of Illinois to refine and assess a digital mindfulness-based intervention (MBI) to improve pain and sleep among adolescents and young adults with sickle cell disease (SCD). The award will support the adaptation of the MBI through user-centered design, evaluation of its feasibility and acceptability, and exploration of its impacts on...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $162,486 to the University of Illinois to conduct research on the role of sleep in the premenstrual exacerbation of depression and suicidality. The 4-year project will utilize high-resolution digital health sleep data from a recently completed clinical trial to identify periods of acute suicide risk and potential sleep-related treatment targets,...
APP-GUIDED BEDTIME MINDFULNESS FOR INSOMNIA - PROJECT SUMMARY THIS K23 AWARD WILL SUPPORT THE CANDIDATE'S TRAINING AND DEVELOPMENT TOWARDS AN INDEPENDENT CLINICAL RESEARCH CAREER FOCUSED ON BEHAVIORAL SLEEP MEDICINE AND THE USE OF REMOTE TECHNOLOGY-BASED DELIVERY/ASSESSMENT OF MINDFULNESS MEDITATION (MM) TO FACILITATE SELF-SLEEP MANAGEMENT IN PATIENTS WITH CHRONIC INSOMNIA DISORDER. BACKGROUND. INSOMNIA IS HIGHLY PREVALENT AND ASSOCIATED WITH A WIDE RANGE OF DELETERIOUS HEALTH CONSEQUENCES. ACCORDING TO WELL-ESTABLISHED DISEASE MODELS, INSOMNIA IS CHARACTERIZED BY BEDTIME STRESS, PRE-SLEEP HYPERAROUSAL, OR HIGH SLEEP REACTIVITY. MM IS A PROMISING INTERVENTION FOR PATIENTS WITH INSOMNIA. THE DELIVERY OF MM VIA MOBILE HEALTH HAS LARGELY INCREASED ACCESS TO SUCH INTERVENTIONS. TECHNOLOGY HAS ALLOWED BOTH REMOTE DELIVERY OF INTERVENTION AND HOME ASSESSMENT WITH PHYSIOLOGICAL RECORDINGS THAT INCREASE ACCESS TO REAL-WORLD DATA. EXISTING STUDIES HAVE MOSTLY FOCUSED ON DAYTIME MM PRACTICE AND SUBJECTIVE SLEEP QUALITY AT NIGHT. IT IS NOT CLEAR WHETHER THE TEMPORAL RELATIONSHIP OF BEDTIME MM PRACTICE IS IMPORTANT TO SLEEP OUTCOMES, WHAT IS THE MOST EFFECTIVE WAY TO DELIVER APP-BASED MM FOR PATIENTS WITH INSOMNIA DISORDER, OR WHETHER PHYSIOLOGICAL CHANGES CORRELATED WITH MINDFULNESS PRACTICE CONTRIBUTE TO SLEEP IMPROVEMENT. SPECIFIC AIMS. THIS K23 PROPOSES A PROOF-OF-CONCEPT FEASIBILITY STUDY WITH AIMS TO: (1) REFINE CONTENT DELIVERY OF AN APP-BASED MM INTERVENTION (SPECIFICALLY FOR BEDTIME USE); (2) EVALUATE THE FEASIBILITY AND ACCEPTABILITY OF THE APP-BASED INTERVENTION IN A PILOT RANDOMIZED CONTROLLED TRIAL; AND (3) EXPLORE PATTERNS OF CHANGE IN SLEEP-RELATED SUBJECTIVE/OBJECTIVE OUTCOMES, INCLUDING REMOTE ASSESSMENT. TRAINING. TO DEVELOP EXPERTISE CRITICAL TO THE CANDIDATE'S OVERALL CAREER GOALS, DR. MA WILL RECEIVE TRAINING IN THREE AREAS: (1) BEHAVIORAL SLEEP MEDICINE AND CLINICAL TRIALS; (2) QUALITATIVE AND MIXED METHODS RESEARCH; AND (3) MOBILE HEALTH (MHEALTH), TECHNOLOGY-BASED SLEEP INTERVENTIONS AND ASSESSMENT. THESE TRAINING AIMS WILL BE SUPPORTED BY STRONG INSTITUTIONAL RESOURCES, AS WELL AS COURSEWORK, TRAININGS, RESEARCH SEMINARS/MEETINGS, AND SCIENTIFIC CONFERENCES. MENTORSHIP. THE CANDIDATE WILL BE SUPPORTED BY AN EXPERT MENTORING TEAM INCLUDING PRIMARY MENTORS JANET MULLINGTON, PHD AND GLORIA YEH, MD, MPH, CO-MENTOR/COLLABORATORS PETER WAYNE, PHD, SUZANNE BERTISCH, MD, MPH, ANA-MARIA VRANCEANU, PHD, JOHN TOROUS, MD, MBI, PAMELA RIST, SCD, AND KAREN KILGORE, PHD. IMPACT. FINDINGS FROM THE PILOT STUDY WILL INFORM THE DESIGN OF A LARGER TRIAL AND FORM THE NECESSARY FOUNDATION TO FURTHER INVESTIGATE MOBILE-HEALTH MM APPROACHES FOR INSOMNIA DISORDER AND UNDERSTAND LINKS BETWEEN PRE-SLEEP MM AND SLEEP QUALITY. BUILDING ON THE CANDIDATE'S EXISTING SKILLS IN PHYSIOLOGICAL SIGNAL ANALYSIS, THIS K23 AWARD WILL ALLOW THE CANDIDATE'S DEVELOPMENT AS A CLINICAL/TRANSLATIONAL RESEARCHER WITH EXPERTISE IN MOBILE TECHNOLOGY-BASED MM INTERVENTION AND ASSESSMENT FOR MANAGEMENT OF SLEEP, AND COMPLEX PHYSIOLOGICAL SIGNALS TO ELUCIDATE THE EFFECTS OF MM ON SLEEP.