Project Grant K23AG101083
- The National Institute on Aging awarded Yale University $839,400 under the Aging Research program (CFDA 93.866) on September 1, 2026, to validate novel algorithms for assessing sleep deficiency in persons with Alzheimer's disease and related dementias. The project addresses the urgent need for feasible, accurate assessment methods for sleep deficiency in ADRD populations, where over half of patients experience sleep abnormalities that accelerate cognitive and functional decline. Existing...
- The National Institute on Aging awarded The University of Chicago $597,239 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support investigation of inpatient rehabilitation facility (IRF) utilization and outcomes for older adult patients with and without Alzheimer's disease or other dementias (ADRD). The research examines comparative value and appropriateness of care delivery across post-acute care settings, specifically comparing higher-cost IRF care—which provides acute...
- The National Institute on Aging awarded $780,217 to the University of Connecticut Health Center on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging of prefrontal cholinergic dynamics and cognitive flexibility in an Alzheimer's disease model. The research combines chronic two-photon imaging, fluorescent acetylcholine reporting, in vivo beta-amyloid labeling, and cell-type-specific chemogenetic and optogenetic control to test whether amyloid-beta...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The University of California, Los Angeles received a $2.7 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion scheduled for August 31, 2029. This research project will generate rigorous evidence comparing health outcomes for older patients with Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) who are discharged from hospitals to home-based care versus facility-based...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded Wake Forest University Health Sciences $633,510 on September 1, 2026, under the Aging Research program (CFDA 93.866) to examine the impact of home-based medical care and telemedicine use on dementia care outcomes among Medicare enrollees with Alzheimer's disease and related dementias. The project will study home-based medical care delivery—house calls by physicians and advanced care providers—and telemedicine use among persons living with Alzheimer's...
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $1,628,644 on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct GOC ADVANCE, a cluster randomized controlled trial testing a communication intervention to improve shared decision-making about goals of care for family decision-makers of nursing home residents with late-stage Alzheimer's disease and related dementias. The trial enrolls 300 participants (150 dyads per study arm)...
The National Institute on Aging awarded Yale University $182,018 on August 15, 2026, through the Aging Research program (CFDA 93.866) to support Dr. Snigdha Jain's career development as an independent investigator leading the development and testing of interventions that improve shared decision-making about critical care interventions for older adults with Alzheimer's disease and Alzheimer's disease-related dementias. The award funds three research aims addressing invasive mechanical ventilation among older adults with dementia hospitalized with pneumonia. In Aim 1, Dr. Jain will conduct a target trial emulation study using electronic health record data from the Veterans Affairs healthcare system linked with VA and Medicare claims to generate treatment effect estimates comparing invasive versus noninvasive respiratory support on patient and family outcomes. In Aim 2, she will use these estimates to adapt a best case/worst case scenario planning intervention—a communication strategy delivering prognostic information through narrative description of plausible futures—for delivery in the intensive care unit to potentially improve shared decision-making. Aim 3 involves testing this communication intervention. The research addresses the fact that more than 100,000 older adults with Alzheimer's disease and related dementias receive invasive mechanical ventilation annually in the United States, a potentially burdensome treatment with uncertain long-term benefit, while noninvasive respiratory support alternatives exist but lack comparative effectiveness data. Place of performance is New Haven, Connecticut. The period of performance runs through April 30, 2031. The award is classified as a Project Grant and carries an assistance type of Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $182.0k | 8/3/26 |