Project Grant K23AG084899
- This Project Grant award of $371,871 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a biopsychosocial investigation into contemporary human models of postoperative pain. The project aims to gain a deeper understanding of the mechanisms underlying nociception and the pain experience in surgical patients. Key activities include examining endogenous pain modulation, pain neurocircuitry,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,000.00 to The Regents of the University of California, San Francisco (UCSF) to develop and implement a prognosis communication tool for older adults receiving post-acute care in skilled nursing facilities (SNFs). The goal is to provide personalized prognostic information to SNF patients about the likelihood of outcomes such as hospital readmission, long-term nursing home transition, and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $636,957 study to investigate the relationship between prescription opioids, brain structure, and cognition in older adults with chronic pain. The single-center, double-blinded, placebo-controlled trial will enroll 200 participants with chronic pain due to osteoarthritis. The primary goal is to determine if opioid exposure is associated with changes in white matter integrity and global...
- This federal Project Grant award, valued at $131,568 and provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), aims to investigate the impact of an improvisation music therapy intervention on reducing behavioral and psychological symptoms of dementia (BPSD) in persons living with dementia (PLWD) and decreasing stress/burden in their caregivers. The proposed research project will: 1) standardize an improvisation music therapy intervention prototype for the...
- This Project Grant award, funded by the Department of Health and Human Services' National Institute on Aging (CFDA 93.866 Aging Research), is for a project titled "Improving Integration of Treatment Burden Information in Primary Care for Older Adults with Multiple Chronic Conditions." The $107,330 award to Beth Israel Deaconess Medical Center, Inc. (BIDMC) will support two key objectives: 1) Developing a scalable model to estimate treatment burden scores for older adults with...
- This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
- This Project Grant award of $238,685 from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research by the University of California, San Francisco (UCSF) to investigate sex-dependent modulation of pain pathways by regulatory T cells. The research aims to elucidate how sex hormones and pregnancy influence an opioid signaling circuit in the spinal cord meninges that confers antinociceptive effects in female mice. This...
- The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...
- The University of Washington was awarded a $388,750 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct a study on the outcomes and experiences of older adults who are transferred between healthcare facilities. The project aims to: 1) characterize the outcomes of older adults who experience interfacility transfers, 2) explore the experiences of older adults and their care partners during transfers, and 3) identify factors influencing transfer decisions...
- This federal Project Grant award of $641,856 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to determine the effects of reduced nursing home capacity on older adults, their caregivers, and post-acute/long-term care access. The project, which runs from September 1, 2025 to May 31, 2030, will conduct rigorous quantitative analyses to assess the implications of nursing home capacity declines, which have accelerated due to the COVID-19 pandemic. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $183,317 to The Regents of the University of California, San Francisco to conduct research focused on pain assessment, treatment, and functional outcomes in hospitalized, older adults. The key objectives of this clinically-grounded, patient-focused project are to: 1) Describe how pain is assessed and treated for older hospitalized adults through retrospective analysis of data from ~30,000 patients; 2) Conduct qualitative interviews and focus groups to understand patient, caregiver, and clinician perspectives on pain during hospitalization; and 3) Prospectively examine the relationship between patient-reported pain, inpatient pain treatment, and post-discharge functional outcomes. This multi-faceted research aims to improve the understanding of how pain is experienced and managed for older adults during and after hospitalization. The award supports the career development plan of Dr. Aksharananda Rambachan to become an independently funded physician-investigator in this area.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/10/25 | ||
| Not listed | $183.3k | 8/13/25 |