Project Grant K22CA296237
- This $147,486 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research at the University of Pittsburgh to understand the impact of altered lipid metabolism on CD8 T cell exhaustion within the tumor microenvironment. The project aims to investigate how increased lipid accumulation influences the differentiation and function of CD8 T cells, which play a key role in anti-tumor immune responses. This 3-year project, running from...
- This $139,917 federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) supports research to investigate how the dietary nutrient zeaxanthin enhances anti-tumor immunity by reprogramming CD8+ T cell function. The award recipient, the University of Chicago, will conduct preclinical studies to demonstrate zeaxanthin's anti-tumor effects and elucidate the underlying molecular mechanisms through which it impacts CD8+ T cell activity. The research...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- The Project Grant award of $424,734 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development of a novel spatial proteomics approach to profile immune cell types and their locations within a tumor microenvironment. The University of Illinois, the awardee, aims to integrate 3D microscopy techniques with bottom-up proteomic assays to offer deep proteome profiles of specific immune cells at various subregions of a mouse tumor (Aims 1 and 2). The goal is...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding to Glytr Therapeutics, Inc. to maximize the effectiveness of their pan-cancer immunotherapy platform based on Glycan-dependent T cell Recruiter (GLYTR) technologies. The $463,510 award, granted on September 10, 2025, supports research to enhance the target density and broaden the applicability of GLYTR1 bi-specific antibodies and GLYTR2 chimeric antigen receptor (CAR)...
- This Project Grant award, funded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower), aims to investigate the potential of a de novo dietary compound called Sumiki's Acid (SKA) as an immunomodulator for cancer immunoprevention. The $113,203 award, granted on August 1, 2025, will support research to determine SKA's ability to enhance natural killer (NK) cell activation and cytotoxicity against cancer cells, as well as evaluate its cancer-preventive effects in mouse models. The...
- This federal Project Grant award of $189,648 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower Program) supports research to elucidate the mechanisms of mitochondrial biogenesis in T cell immunity. The project aims to investigate the role of the gene PPRC1 in regulating mitochondrial mass and metabolism in T cells, and how T cell receptor signaling induces PPRC1 expression to drive a unique transcriptional program necessary for mitochondrial biogenesis. This research has...
- This federal Project Grant award, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research focused on understanding the relationship between inflammatory signaling in the leptomeninges and the growth of leptomeningeal metastatic tumors. The $730,398 award to the Sloan-Kettering Institute for Cancer Research, located in New York, will leverage mouse models and single-cell RNA sequencing to investigate how cancer cell signals induce...
- This federal Project Grant award of $1,612,104.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research conducted by the University of Chicago to develop senescent tumor cell-loaded dendritic cell vaccines for breast cancer. The research aims to transform healthcare for military service members, veterans, and the broader public by advancing innovative medical solutions to critical health challenges. The 3-year...
This federal Project Grant award of $185,760 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) aims to support research to investigate the role of glycerol metabolism in anti-tumor immunity. The research, conducted by the University of Chicago, will determine the immunomodulatory effects of glycerol on CD8+ T cells and examine the metabolic interactions between cancer cells and T cells. The project will also explore methods to improve anti-tumor immunity by manipulating glycerol signaling. This award is part of the NCI's efforts to advance scientific understanding of cancer and develop new therapeutic approaches, with a focus on the impact of metabolic factors like glycerol on the tumor microenvironment and immune response. The award has a performance period from September 15, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $185.8k | 9/12/25 |