Project Grant K22CA292575
Award Date 4/1/25
Completion Date 3/31/28
Dollars Obligated $190K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
- This federal Project Grant award of $153,768 from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) aims to elucidate the impact of peroxisome biogenesis on adaptive immune responses, particularly within the tumor microenvironment and anti-tumor immunity. The principal investigator at The Medical University of South Carolina will conduct research to delineate the mechanisms by which peroxisome capacity influences T cell exhaustion, lipid accumulation, and...
- This $147,486 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research at the University of Pittsburgh to understand the impact of altered lipid metabolism on CD8 T cell exhaustion within the tumor microenvironment. The project aims to investigate how increased lipid accumulation influences the differentiation and function of CD8 T cells, which play a key role in anti-tumor immune responses. This 3-year project, running from...
- This federal Project Grant award of $663,340 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to elucidate the mechanisms by which the ablation of intratumoral regulatory T cells can mobilize NK cells and CD4 T cells to control MHC I-deficient tumors. The research aims to determine how CD4 T cell help enhances the antitumor function of NK cells, including the role of cytokines like IL-2 and IL-15, as well as test whether intratumoral Treg depletion...
- This federal Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) provides $153,348 to The Trustees of Columbia University in the City of New York to conduct in-depth mechanistic and in vivo functional studies of single-nucleotide variants (SNVs) that modulate T cell activity for cancer immunotherapies. The research aims to define the mechanisms by which certain PIK3CD SNVs enhance T cell activity and evaluate their impact in murine...
- This federal Project Grant award of $185,760 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) aims to support research to investigate the role of glycerol metabolism in anti-tumor immunity. The research, conducted by the University of Chicago, will determine the immunomodulatory effects of glycerol on CD8+ T cells and examine the metabolic interactions between cancer cells and T cells. The project will also explore methods to improve anti-tumor immunity by...
- This $549,460 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida to study the role of the BCL11B transcription factor in regulating CD8+ T cell response and memory in tumor microenvironments. The award aims to establish the transcriptional programs and epigenomic landscape controlled by BCL11B in mouse T cells, with the goal of understanding...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This federal Project Grant award of $194,914 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the role of trans-acting factors and cis-element sequences in activating oncogenes in rearranged human genomes. The awardee, the University of Texas Health Science Center at Houston, will employ CRISPR/Cas9 genome engineering to introduce chromosomal translocations near oncogenes and model their expression using single-cell multi-omic...
- This $149,804 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research at the University of Pittsburgh to investigate the impact of the LAG3 receptor on CD8+ T cell motility and migration in the context of cancer immunotherapy. The research aims to elucidate how LAG3 functions to restrict T cell motility, and determine if LAG3 affects CD8+ T cell infiltration and interactions within the tumor microenvironment. The research combines...
This federal Project Grant award of $189,648 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower Program) supports research to elucidate the mechanisms of mitochondrial biogenesis in T cell immunity. The project aims to investigate the role of the gene PPRC1 in regulating mitochondrial mass and metabolism in T cells, and how T cell receptor signaling induces PPRC1 expression to drive a unique transcriptional program necessary for mitochondrial biogenesis. This research has implications for enhancing T cell-based immunotherapies and improving tumor control. The award was made to the University of Miami and has a performance period from April 1, 2025 to March 31, 2028.
Generated 10/21/25, 5:12 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $189.6k | 9/12/25 |