Project Grant K08NS138676
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $429,000 Project Grant to the Regents of the University of Michigan on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, funds research to identify the mechanism of Notch pathway inhibition resistance in glioblastoma (GBM) stem cells. The...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $131,360 to the University of New Haven, Incorporated, effective September 1, 2025, through August 31, 2029, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This research initiative focuses on characterizing glioblastoma stem cell (GSC)-associated long noncoding RNA (lncRNA) GIHCG as a potential therapeutic target...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a Project Grant award of $229,078 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 11, 2025, with a completion date of July 31, 2030. This research initiative focuses on ferroptosis sensitization in glioblastoma, a highly aggressive form of brain cancer....
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $499,516 Project Grant to The Leland Stanford Junior University, effective February 1, 2026 through January 31, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This research initiative develops a novel imaging strategy to optimize immunotherapy for brain tumors, specifically glioblastoma, by creating a first-in-class...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $599,005 project grant to the University of Miami's Office of Research Administration on August 21, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will be conducted in Florida and is scheduled for completion by July 31, 2030. This award supports investigator-initiated basic and translational research...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a Project Grant of $659,325 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through June 30, 2029. This research initiative investigates neuro-immune mechanisms in mutant IDH1 (isocitrate dehydrogenase 1) gliomas to advance understanding of how IDH1 mutations...
- Federal Project Grant Award Summary The University of Pittsburgh received a $443,354 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 15, 2025, with completion scheduled for April 30, 2030. This research initiative targets metabolic vulnerabilities in diffuse midline gliomas (DMG) with H3K27A mutations, pediatric brain tumors carrying a...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $521,839 Project Grant to the University of California, San Diego under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on August 7, 2025. The award supports a five-year research initiative (through July 31, 2030) investigating the molecular mechanisms of pathogenic microglial populations in central nervous system (CNS)...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham a project grant of $339,436 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 4, 2025, with completion targeted for July 31, 2030. The award funds research targeting radiation-induced glioblastoma invasion, specifically addressing the aggressive invasive behavior that emerges in...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $628,373 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on August 1, 2025, for a five-year project period extending through June 30, 2030. This Project Grant supports fundamental and translational research focused on understanding the immunobiology of conventional dendritic cells (CDC1) and their...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania a Project Grant totaling $215,350 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports a research and career development initiative led by Dr. Jackson, an Assistant Professor of Neurosurgery at the University of Pennsylvania, through the project period ending January 30, 2031. The grant funds investigator-initiated research focused on BCAT1-targeted metabolic reprogramming in myeloid-derived suppressor cells (MDSCs) in glioblastoma, with the objective of transitioning Dr. Jackson from a mentored researcher to an independent investigator capable of conducting translational research in brain tumor immunobiology. The funded research deliverables encompass basic and translational neuroscience research aimed at developing novel immune-based therapies against glioblastomas. Key research activities include technical development in metabolite measurement and metabolic flux analysis using mass spectrometry and stable isotope tracing, advanced gene knockout methodologies, and conditional knockout mouse model development for preclinical therapeutic testing. The award supports Dr. Jackson's acquisition of specialized expertise under mentorship from recognized leaders in cancer immunometabolism and T cell biology, with the ultimate goal of translating laboratory findings into clinically relevant therapeutic trials targeting the immunosuppressive role of MDSCs in brain tumors.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $215.4k | 3/1/26 |