This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to establish the molecular, cellular, and transcriptional mechanisms that regulate reactive astrocyte phenotypes in the optic nerve head and Müller glia, and their impact on retinal ganglion cell survival in a mouse model of glaucoma. The $1,130,220 award, with a project period from September 1, 2024 to April 30, 2029, will utilize state-of-the-art single cell...
This federal Project Grant award of $638,267 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to develop treatments for optic neuropathy in familial dysautonomia, a severe neurodegenerative disorder. The research aims to evaluate the efficacy of systemic and local therapeutic approaches to rescue visual function, as well as investigate the underlying molecular mechanisms of retinal ganglion cell loss in this condition. The project will use...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is providing $184,238 to The Leland Stanford Junior University (Stanford University) from January 1, 2025 to December 31, 2026. The funding supports research to evaluate the functional impact of retinal ganglion cell (RGC) loss during the progression of neurofibromatosis type-1 (NF1) optic glioma, and to assess whether transplanted RGCs can integrate into and interact with...
The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a 4-year $665,243 Project Grant to The Ohio State University to investigate methods to enhance retinal ganglion cell (RGC) survival and optic nerve regeneration. The research aims to develop novel autologous myeloid cell therapies that can promote visual recovery in individuals with optic nerve injuries or optic neuropathies. Specifically, the project will: 1) elucidate the factors secreted...
This $460,625 federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to investigate the underlying cellular and synaptic mechanisms that explain changes in retinal ganglion cell (RGC) activity following optic nerve injury. The two-year project, awarded to Yale University, aims to determine how different types of RGC are impacted by increased intraocular pressure or direct optic nerve crush, and to validate methods for...
This $474,337 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to determine the origins and vulnerabilities of pediatric treatment-induced gliomas. The award aims to discover germline risk factors for radiation-induced gliomas, identify key pathways driving tumor growth and treatment resistance, and test combination therapies...
The National Eye Institute (NEI) awarded a $387,428 Project Grant (CFDA 93.867 Vision Research) to The Research Foundation For The State University Of New York, operating as Upstate Medical Center, to investigate mechanisms that drive optic nerve sensitivity to elevated intraocular pressure in glaucoma. The research aims to: 1) Determine how optic nerve head astrocytes integrate transient biomechanical strains to predispose to future glaucomatous dysfunction; 2) Explore the link between...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), is providing $1,682,553.00 in funding to The Children's Hospital Corporation, doing business as Boston Children's Hospital, for a 5-year project period from May 1, 2024 to April 30, 2029. The grant supports research to investigate mechanisms for promoting myelination of regenerating axons in the central nervous system (CNS) in order to restore vision, a...
This federal Project Grant award of $606,034 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to investigate the role of Müller glia in the acute and chronic inflammatory response in the retina under various stress, injury, and disease conditions. The project aims to provide a deeper understanding of the molecular and cellular mechanisms that maintain retinal homeostasis and how those mechanisms are disrupted during acute and chronic retinal...
This federal Project Grant award in the amount of $416,265 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, is funding research to investigate the impact of low-grade glioma infiltration on cortical structure and function. The primary awardee, The Regents of the University of California, San Francisco (UCSF), will use the funding to: 1) Define the...