Project Grant K08MH142848
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $701,763 on April 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ventral CA1 hippocampal subregion in valence-associated social memories and emotional memory processing. The five-year project, which runs through January 31, 2031, will uncover the neural circuits mediating positive and negative social memories, identify hippocampal cell types supporting...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at...
- The National Institute of Mental Health awarded Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $818,498 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how individual differences in hippocampal gene expression modify susceptibility and resilience to depression following early adversity in adolescents. The research will determine whether innate variation in expression of adversity-,...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $839,815 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a clinical and translational research project investigating neuroimmune mechanisms of depression and anhedonia. The project tests the hypothesis that heightened peripheral immune function and increased blood-brain barrier permeability contribute to major depressive disorder and anhedonia severity. Work is...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. $450,175 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of hippocampal dopamine in early life adversity effects on fear generalization. The award funds basic neuroscience research examining how dopamine and norepinephrine release from locus coeruleus projections to the ventral dentate gyrus of the hippocampus dynamically control and...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $717,688 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate molecular and epigenetic mechanisms by which postpartum stress interacts with parity to influence vulnerability to perinatal and postpartum mood and anxiety disorders. The recipient will use a parity-by-postpartum-stress mouse model to examine how stress dysregulates dopamine responsiveness via projections...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $763,265 on August 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize splicing and isoform dysregulation in autism spectrum disorder at cellular resolution. The recipient will profile postmortem prefrontal cortex brain tissue from 74 individuals with ASD and 74 neurotypical controls across the lifespan, from childhood to adulthood, using long-read multiplexed arrays...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $169,701 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct multiomic and spatial profiling of hippocampal development and subfield specification. The research deploys single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and spatial sequencing on human fetal hippocampal and neocortical tissue (gestational weeks 16–24) and human induced pluripotent stem cell–derived three-dimensional organoids. The first aim examines the role of Wnt and BMP signaling in committing cortical radial glia to the hippocampal lineage using in vitro hippocampal organoids. The second aim applies spatial sequencing to developing fetal hippocampus to identify novel markers defining hippocampal subfields, catalog cell types present and absent in organoid models, and validate newly identified candidate pathways controlling subfield fate specification. The project will generate a comprehensive multiomic atlas of the developing hippocampus and establish the hippocampal organoid as a tool for modeling neurodevelopment and disease relevant to neuropsychiatric disorders. Performance occurs in New York, New York from September 1, 2026, through August 31, 2030. The award is classified as a Project Grant under the K08MH142848 designation, a K-series individual award mechanism supporting career development for clinician-scientists and basic scientists conducting mental health research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $169.7k | 9/1/26 |