This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $760,143 to the University of Maryland, Baltimore to support research on the role of the endocannabinoid system and cholinergic signaling in memory processes and reward-seeking behavior. The research will investigate how the deletion of cannabinoid type 1 receptors on cholinergic terminals in the hippocampus impacts working memory and motivation,...
The National Institute of Mental Health (NIMH) awarded a $775,706 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh on August 9, 2024. The funding will support a prospective study examining the neural, molecular, and functional impacts of reducing anticholinergic burden (ACB) in 80 individuals aged 40-70 with schizophrenia spectrum disorders. The study aims to understand the effects of ACB reduction on cognition, quality of life, neural mechanisms...
This $1,537,147 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a study to use positron emission tomography (PET) to investigate the role of the endocannabinoid system, specifically the enzyme fatty acid amide hydrolase (FAAH), in depression and suicide among young adults. The study will compare FAAH levels in the brains of individuals with major depression and recent suicide attempts, those with...
This federal Project Grant award for $220,340 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research investigating the role of microglia as a mechanism of medial prefrontal cortex dysfunction following adolescent cannabis exposure. The two-year project, awarded to Washington State University starting in September 2024, aims to determine whether microglial activation is necessary for the cognitive flexibility deficits...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research on the impact of cannabis legalization and commercialization on substance use and mental health outcomes among individuals with psychosis. The $177,110 award will enable the principal investigator, an early career psychiatrist and health services researcher, to use quasi-experimental difference-in-difference methods to analyze national...
The National Institute of Mental Health (NIMH) awarded a $187,635 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Washington to develop and pilot test an intervention for families of young adults with first-episode psychosis who frequently use cannabis. The goal is to teach families skills to increase motivation among their young adult relatives to reduce cannabis use, as heavy cannabis use is associated with negative mental health and functional outcomes in this...
The federal Project Grant award R01DA057317, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), will support research to investigate the effects of cannabinoid exposure on neurodevelopment and behavior. The $800,267 award, spanning from July 1, 2024 to May 31, 2029, will utilize a zebrafish model system to: 1) measure morphological and behavioral alterations in anxiety and locomotion; 2) assess...
This $3,085,041 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a longitudinal study on adolescent brain maturation and its relationship to psychiatric disorders. The University of Pittsburgh, as the prime awardee, will use advanced neuroimaging techniques at 7 Tesla MRI to examine neuropil growth/contraction and multiplex network dysconnectivity in 210 adolescent subjects, including those at...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $350,000 in funding to Creighton University to conduct research on the developmental effects of environmental enrichment on minor cannabinoid drug reward and cannabinoid receptor levels. The research aims to investigate whether exposure to high- or low-novelty environments during adolescence can alter sensitivity to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,383,618.00 to The Johns Hopkins University to study the effects of adolescent cannabis use on prefrontal cortex maturation and cognitive function. The key objectives are to investigate how microglia, a type of immune cell in the brain, mediate the adverse impacts of tetrahydrocannabinol (THC) from cannabis on the development of the prefrontal...