Project Grant K08HL185896
- Federal Project Grant Award Summary Yale University received a $671,373 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion scheduled for March 31, 2030. The grant funds basic biomedical research investigating ferroptosis regulation in lung inflammation and injury, with the ultimate objective of elucidating cell non-autonomous protective mechanisms against ferroptotic cell...
- Federal Grant Award Summary Yale University received a $1.498 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 23, 2025, with a completion date of August 31, 2027. The award funds research investigating the molecular mechanisms of sex differences in scleroderma-associated interstitial lung disease (SSc-ILD), specifically examining the role of mitochondrial DNA (mtDNA) and Toll-like...
- Federal Grant Award Summary Yale University received a $1.54 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for May 31, 2029. The project, "Endothelial Protocadherins in Vascular Development and Disease," delivers mechanistic research investigating gamma protocadherins (PCDHG) as regulators of vascular stability and inflammation. The...
- Federal Project Grant Award Summary Yale University received a $958,850 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2029. This research project focuses on investigating interleukin-1 (IL-1) signaling mechanisms in critically ill children with bronchiolitis to identify disease severity markers and develop therapeutic interventions. The...
- Federal Project Grant Award Summary Yale University received a $126,177 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 17, 2026, with a completion date of April 30, 2028. The award supports investigative research examining the role of Intraflagellar Transport 88 (IFT88), a primary cilia protein, in regulating smooth muscle cell phenotype and vascular remodeling in the context of...
- Federal Project Grant Award Summary Yale University received a $1,475,805 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion expected June 30, 2029. The grant supports fundamental biomedical research into heterochromatin dynamics in vascular smooth muscle (SMC) plasticity—specifically, how mature vascular smooth muscle cells alter their phenotype in response to...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $165,456 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion scheduled for June 30, 2030. This award supports fundamental research investigating the role of protein S-palmitoylation in transforming growth factor beta (TGF-β) signaling and its contribution to...
- Federal Grant Award Summary Yale University received a $1.68 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for April 30, 2028. This award funds research into the developmental mechanisms that drive vascular resiliency in the Circle of Willis (CW), a critical collateral circulatory system connecting arteries to ensure oxygenated blood supply to the...
- Federal Grant Award Summary Yale University received a $347,112 Project Grant award effective September 5, 2025, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The PAP-Flow Study will investigate the impact of positive airway pressure (PAP) therapy on myocardial blood flow in adults with obstructive sleep apnea (OSA) at high cardiovascular disease risk. The research will recruit 60 individuals with moderate,...
- Federal Project Grant Award Summary Yale University received a $445,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2026, through July 31, 2028. The award funds development and application of Deuterium Metabolic Imaging (DMI) technology to non-invasively map cardiac glucose metabolism and detect ischemic conditions in the heart. DMI uses deuterated compounds (such as...
Yale University received a $165,564 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 5, 2026, through June 30, 2031. The award funds a physician-scientist career development initiative focused on advancing research into the neurobiology of idiopathic pulmonary fibrosis (IPF), a fatal progressive lung disease characterized by myofibroblast-driven tissue scarring. The research investigates the role of adrenergic nerve-derived noradrenaline and A1-adrenoreceptor signaling in sustaining myofibroblast activation and fibrosis progression. The awardee will deliver research training, advanced coursework, and career development activities designed to establish an independent research program distinct from his mentor's work. Mentoring and advisory support will be provided by Dr. Herzog (primary mentor, IPF neurobiology specialist), Dr. Dixit (adrenergic innervation expert), Dr. Sinha (noradrenaline and adrenoreceptor authority), Dr. Gonzalez (humanized model expert), and Dr. Sauler (lung genomics specialist). Yale School of Medicine has committed 75% of the awardee's time to career development and pledged institutional support through its biomedical research infrastructure and mentorship programs. The deliverables include mechanistic research publications advancing understanding of neuroimmune pathways in IPF and development of therapeutic targets based on A1-adrenoreceptor antagonism.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $165.6k | 7/8/26 |