Project Grant K23HL179513
- This $764,853 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Yale University supports research to understand the role of arousal threshold (ARTH) as a determinant of adherence and outcomes for continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea (OSA). The research aims to validate ARTH as a biomarker to guide precision OSA therapy, as poor adherence and inconsistent impacts on neurocognitive and...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to elucidate the complex relationship between obstructive sleep apnea (OSA) and cardiovascular disease (CVD). The $1,296,660 award supports a 24-month research project that will employ a "bed to bench" approach integrating clinical, computational, and in vitro techniques. Key objectives include developing and validating a mathematical model to quantify...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,415,112 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Nebraska Medical Center (UNMC) to evaluate a telehealth-delivered adaptive intervention for improving continuous positive airway pressure (CPAP) therapy adherence and health outcomes in adults with obstructive sleep apnea (OSA). The project aims to: 1) compare effects of motivational enhancement, device support, and...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $248,088 to the University of California, San Diego (UCSD) to conduct a mechanistic study on cardiovascular outcomes in patients with comorbid obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), referred to as overlap syndrome (OVS). The central hypothesis is that poor cardiovascular outcomes in OVS, compared to COPD or OSA alone,...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $818,279 to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on improving the subtyping and characterization of obstructive sleep apnea (OSA). The project will leverage data from existing research cohorts and a clinical biobank to quantify the reproducibility of OSA severity markers and derive physiologically...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $450,000 in funding to Old Dominion University to investigate the relationship between disturbed sleep and the development of vulnerable atherosclerotic plaques. The primary objectives are to: 1) examine the role of NADPH-dependent oxidative stress in accelerating the formation of vulnerable atherosclerotic plaques in...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $816,472 project grant to the Icahn School of Medicine at Mount Sinai (ISMMS). The grant, awarded on August 1, 2025 and set to conclude on May 31, 2029, aims to enhance cardiovascular risk prediction and treatment response in obstructive sleep apnea (OSA) patients using advanced AI-based transformer models and multi-modal sleep data. The project will...
- This federal Project Grant award of $115,125.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the interaction between obstructive sleep apnea (OSA) and HIV infection on ventricular repolarization abnormalities. The research will be conducted by the University of Miami from February 1, 2025 to January 31, 2027. The goal is to delineate the independent and interactive effects of OSA and HIV on QT variability...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the oxygen cost of breathing and its impact on dyspnea and exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). The award aims to understand how obesity-related mechanical ventilatory constraints...
This Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to study the impact of positive airway pressure (PAP) therapy on myocardial blood flow in adults with obstructive sleep apnea (OSA) at high risk of cardiovascular disease. The $173,556 award to Yale University will recruit 60 individuals with moderate PAP-naive OSA to test the hypotheses that OSA-specific measures of hypoxia and autonomic response are associated with abnormal left ventricular (LV) myocardial flow reserve, and that PAP use can improve abnormal LV and right ventricular myocardial blood flow. The researchers will conduct cardiac PET stress tests to assess myocardial flow reserve before and after one week and four months of PAP therapy in participants with abnormal baseline LV myocardial flow reserve.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $173.6k | 9/4/25 |