Project Grant K08DK143334

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $165K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
Similar Awards
This $524,837 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by The Ohio State University to better understand the role of enteric glial mechanotransduction and mechanical stress in postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to: 1) Determine the role of the glial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to determine the mechanisms by which esophageal stretch activates vagal afferent nerves. The $594,956 award, effective January 1, 2025 through November 30, 2028, will support research at the University of South Florida to identify the mechanosensitive receptors and sodium channels responsible...
This $364,324 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the role of epigenetic memory in intestinal stem cell function and regeneration. The award, with a project period from July 2024 to March 2027, will be administered by the Regents of the University of California, San Francisco (UCSF), a leading academic...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $125,000.00 to the Scripps Research Institute in La Jolla, CA to conduct research on the structural mechanics and functional mechanisms of the PIEZO ion channels. The research aims to determine the unique structural characteristics that underlie the functional differences between the PIEZO1 and PIEZO2 channels, as well as...
This Project Grant award, with a total funding amount of $332,350.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support research to investigate the mechanisms of mechanosensation and inflammation-induced hypersensitivity in sensory neurons that innervate the colon, with the goal of revealing potential therapeutic targets for abdominal...
This federal Project Grant award of $551,112 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is designed to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The project aims to 1) test whether impaired DCS cell responses exacerbate colonic inflammation and/or limit tissue repair, 2) define the function of activated DCS...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to provide a mechanistic framework for understanding the physiology of the upper urinary tract. The $577,420 award will support research to define the transcriptional signaling mechanisms and protein complexes required for the development of pacemaker cells that drive urinary tract...
This Project Grant award of $232,875 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to investigate the mechanisms underlying gastrointestinal dysfunction in individuals with Down syndrome. The principal investigator at Virginia Commonwealth University will conduct in vitro assays and electrophysiological studies using a mouse model to test the hypothesis that...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $522,342 to the University of North Carolina at Chapel Hill to conduct research on signaling pathways that mediate epithelial cell injury in the neonatal intestine. The research aims to characterize new signaling mechanisms regulating intestinal epithelial injury in necrotizing enterocolitis (NEC), determine how...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $117,000.00 to the Regents of the University of Michigan to conduct research on the role of substance P and its receptor MRGPRX2 in irritable bowel syndrome (IBS) pathophysiology. The project aims to delineate the underlying mechanisms of bidirectional crosstalk between sensory neurons...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $164,700 to the University of California, Davis (UC Davis) to investigate the role of the mechanosensitive ion channel, Piezo1, in the regulation of smooth muscle cell calcium signaling during intestinal development. The 5-year grant, with an award start date of July 1, 2025, will support research aimed at defining the distribution and function of Piezo1 in smooth muscle cells of the developing intestine, as well as determining the developmental consequences of Piezo1 deficiency on intestinal contractility. This research seeks to provide new insights into the mechanical regulation of smooth muscle cell calcium signaling during intestinal maturation, which is critical for understanding and addressing intestinal dysmotility in premature infants, a significant yet understudied complication of prematurity.

Generated 6/17/25, 2:31 AM