Project Grant K08DK141910
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This $168,296 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Weill Medical College of Cornell University. The grant supports a 5-year research career development program focused on investigating the role of a key enzyme in group 3 innate lymphoid cells (ILC3s) that regulates gut physiology. The central hypothesis is that ILC3s possess...
- This federal Project Grant award of $228,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and promoting tissue protection in inflammatory bowel diseases (IBD) such as ulcerative...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This federal Project Grant award of $458,047.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to understand how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). Specific objectives include identifying...
- This federal Project Grant award of $155,443 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the role of blood vessel endothelial cells in intestinal regeneration and inflammatory bowel disease. Led by Dr. Brisa Palikuqi at Yale University, the research utilizes mouse models, immune profiling, single cell RNA sequencing, and spatial transcriptomics...
- This federal Project Grant award of $242,100.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research by Mayo Clinic to investigate the role of sphingolipid metabolism in regulating regulatory T cell function and intestinal homeostasis, with the goal of developing new therapeutic strategies for inflammatory bowel disease. The project...
- This $859,704 Project Grant was awarded on July 2, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by Weill Medical College of Cornell University to investigate the role of the protein AGR2 in regulating host-microbe interactions and inflammatory processes in Crohn's disease. The research aims to enhance understanding of the cellular...
- This $172,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the causes of inflammatory bowel disease (IBD) therapy failure. The principal investigator, Dr. Simon M. Gray, a gastroenterologist at the University of North Carolina at Chapel Hill, will leverage a pre-clinical mouse model to study the immunologic and...
- This federal Project Grant award of $147,486 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research to investigate the role of gut microbes in regulating interleukin-22 (IL-22) levels in the pancreas and the impact on pancreatic health and disease. The research aims to determine how gut microbe-induced IL-22 affects pancreatic gene expression and the underlying cellular mechanisms, as well as the beneficial and detrimental effects of this...
This $164,188 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The 5-year grant supports training and research at the University of Washington to study the role of intestinal chondroitin sulfate glycosaminoglycans in inflammatory bowel disease. The research aims to determine how changes in the composition of these gut matrix components may contribute to the pathogenesis and progression of inflammatory bowel disease. The project will be led by an early-career investigator with support from an experienced mentorship team and access to specialized research facilities at the university.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $164.2k | 9/4/25 |