Project Grant K08DK140604

Award Date 7/15/24
Completion Date 5/31/29
Dollars Obligated $174K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
Similar Awards
This $725,077 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the immunopathogenesis of necrotizing enterocolitis (NEC) in preterm infants and develop innovative interventions to interrupt the deleterious inflammatory response that leads to this devastating intestinal disease. The primary recipient, the University of North Carolina at Chapel Hill, will leverage...
This Project Grant award of $630,847 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Children's Mercy Hospital in Kansas City, Missouri. The research aims to investigate how the genetic regulator SIGIRR promotes intestinal barrier function and prevents necrotizing enterocolitis (NEC), a life-threatening condition in preterm infants....
This Project Grant award, valued at $378,272 and provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), will fund research to explore the use of inter-alpha inhibitor proteins (IAIP) as a potential therapeutic agent for necrotizing enterocolitis (NEC) - a serious inflammatory condition affecting premature infants. The research aims to obtain proof-of-concept for IAIP replacement...
The National Institute of Child Health and Human Development (NICHD) awarded a $398,750 Project Grant (CFDA 93.865) to the University of Oklahoma (OU) to conduct research on the role of creatine metabolism in necrotizing enterocolitis (NEC), a serious gastrointestinal disease affecting preterm infants. The research aims to test the hypotheses that creatine deficiency detrimentally affects preterm infant intestinal epithelial injury, while creatine supplementation can prevent NEC-like injury. The...
This $731,451 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to model and understand the pathways of early growth dysregulation at the gastroesophageal junction (GEJ) cardia. The research aims to generate GEJ-cardia-derived organoid models using CRISPR-Cas9 genome editing to study the cellular biology and lipidomic profiles of early...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $722,908 to The Children's Hospital of Philadelphia (CHOP) to conduct research aimed at preventing and treating Hirschsprung-associated enterocolitis (HAEC), a life-threatening complication of Hirschsprung's disease. The key goals of the research are to: 1) analyze stool metabolites,...
This $159,362 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to characterize how breast milk IgA shapes the development of the preterm infant gut microbiome and promotes resistance to pathobionts. The primary goals are to: 1) Determine if maternal IgA binding restricts colonization of Enterobacteriaceae and promotes the establishment of obligate anaerobes...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,568.00 to support research aimed at elucidating the mechanisms of Notch signaling in intestinal stem cells. The key objectives of the research are to: 1) define the Notch niche for intestinal stem cells throughout development; and 2) investigate whether intestinal stem...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is for a $683,916 project to develop a novel probiotic delivery system to prevent and treat neurodevelopmental impairment (NI) in premature infants. The central focus is on using a protective biofilm-encapsulated probiotic, Limosilactobacillus reuteri (LR), to mitigate the effects of necrotizing enterocolitis...
This Project Grant award of $497,370 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the CD45 phosphatase in regulating neutrophil function and inflammatory responses during intestinal inflammation. The research, to be conducted by the Regents of the University of Michigan, aims to determine the effects of...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $174,114 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on signaling pathways that regulate intestinal epithelial cell injury in necrotizing enterocolitis (NEC), a devastating gastrointestinal disease that affects premature infants. The studies aim to characterize new signaling mechanisms, determine how microbial metabolites modulate these pathways, and identify potential dietary strategies or therapeutic targets to attenuate intestinal injury in NEC. The research will utilize specialized mouse models, a humanized NEC model, and a microfluidic model incorporating human neonatal intestinal epithelium. This 5-year project, led by a neonatologist-scientist at UNC-CH, is expected to advance the understanding of the anti-inflammatory signaling pathways in the neonatal intestine and support the development of new interventions to improve health outcomes for vulnerable preterm infants.

Generated 4/29/25, 4:43 AM