This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research to understand the role of autoimmune processes in causing podocyte injury and nephrotic syndrome. The $796,293 award to Brigham & Women's Hospital aims to establish the pathogenic mechanisms of anti-nephrin autoantibodies and their effects on podocyte...
This $400,000 Project Grant was awarded on September 9, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research at the University of Texas Southwestern Medical Center to understand the earliest stages of podocyte injury in collagen IV nephropathies, which can lead to chronic kidney disease and end-stage renal failure. The research aims to...
This $174,128 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to discover the consequences of genetic variation in nephrin on kidney diseases and traits in biobank populations. The award was granted to The Children's Hospital Corporation, doing business as Boston Children's Hospital, a non-profit pediatric medical research and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $820,119 to The Washington University in St. Louis to better understand the mechanisms that ensure podocyte homeostasis and the pathogenic mechanisms that promote podocyte foot process effacement and detachment in glomerular diseases. The project aims to elucidate the functions of...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $238,184 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant supports the development of an easy-to-use 3D in vitro model of the developing nephron that can spatially pattern the extracellular matrix, stromal cells, and soluble factors. This microphysiological system aims to enable researchers to investigate the...
This federal Project Grant award for $254,990.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to understand kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The key objectives are to: 1) examine whether co-culturing engineered endothelial cells in kidney organoids enables...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of insulin resistance in the development of renal disease during prepubertal childhood obesity. The $400,000 award, granted on September 5, 2024, will support research at the University of Mississippi Medical Center to examine how insulin resistance...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $700,619 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania to study and control rhythmic nephron induction for kidney replacement tissues. The goal is to gain temporal control over the periodic commitment of nephron progenitors to new nephrons, which is critical for scaling up the production of kidney...
This federal Project Grant award of $892,433 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to provide a more detailed understanding of how upstream eicosanoid pathways relate to the development of chronic kidney disease (CKD) and associated cardiovascular risk. The award will fund research to: (i) identify eicosanoid pathways underlying CKD progression and...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of glycosphingolipids in the development and progression of kidney disease associated with obesity and diabetes. The $830,500 award will fund a 4-year research project at Georgetown University to test the hypothesis that increases in...