The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of T cell immune responses to the oral pathogen Aggregatibacter actinomycetemcomitans (AA) in the development of periodontal disease. The $248,627 award, effective from January 1, 2025 to December 31, 2029, will fund two primary research aims: 1) Assessing systemic T cell responses...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,705,144 to the University of Pittsburgh to support research aimed at developing novel regenerative therapies for periodontal disease. The key objectives of this 5-year project are: 1) identifying cell surface markers to isolate and characterize human periodontal ligament stem cells expressing the PRX1 transcription...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Medical University of South Carolina (MUSC) to conduct research on the role of CD38 signaling in aging-associated immune responses induced by oral bacterial pathogens. The goal is to determine if inhibition of CD38 can attenuate inflammatory bone loss and alleviate aging-associated immune responses caused by oral pathogens like...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research focused on understanding the role of CD4+ memory T cell subtypes in the recurrence of periodontal disease. The $248,999 award will be used to: 1) Identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) Elucidate the pathogenic potential of CD4+ memory T cell subtypes in...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis. The award, totaling $304,019, will enable the prime awardee, Panorama Research Incorporated, to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to identify a lead antibody...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $858,000 to the University of Texas Health Science Center at Houston to investigate the role of the bacterium Veillonella in regulating the inflammatory effects of the oral pathogen Porphyromonas gingivalis. The key objectives are to: 1) explore the mechanisms by which Veillonella inhibits the hemolytic (red blood...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $873,546 to develop an "oral micro-drug factory" using engineered Lactobacillus reuteri bacteria to locally deliver the anti-inflammatory cytokine interleukin-10 (IL-10) for treating periodontitis. The goals are to validate the ability of the engineered bacteria to treat experimental periodontitis and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $148,569 to The Regents of the University of Michigan to conduct research on noninvasive quantitative techniques for detecting periodontal diseases. The key objectives are to: 1) investigate longitudinal periodontal ultrasound data and assess the effect of inflammation on ultrasound attenuation, 2) conduct texture...