Project Grant K08CA312446
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a $680,598 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, with a completion date of August 31, 2030. The award supports fundamental research focused on decoding the Cullin-5 (CUL5) E3 ubiquitin ligase complex to engineer therapeutic T cells with enhanced durability and sustained effector function. The project...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $677,787 to The Regents of the University of California, San Francisco on August 26, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award supports a five-year research initiative (through July 31, 2030) investigating AIRE-expressing tumor-associated macrophages (AIRE+ TAMs) as novel mediators of tumor immune evasion. The research aims to characterize the molecular and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $680,597 to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) on April 1, 2026, for a five-year project extending through March 31, 2031. The project focuses on developing and executing genome-wide CRISPR loss-of-function screens in human CD4+ and CD8+ T cells to identify G protein-coupled receptor (GPCR) pathway targets that enhance chimeric antigen...
- The National Cancer Institute awarded the University of Southern California $137,459 under the Cancer Research Manpower program (CFDA 93.398) on June 1, 2026, to support structured research training and workforce development in cancer immunotherapy. The award funds a K01 career development grant focused on developing a spatially controlled priming system for chimeric antigen receptor (CAR) T cell therapy in solid tumors using focused ultrasound technology. The research deliverables include...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $663,340 Project Grant to the University of California, Berkeley under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The award, made on August 27, 2025 with completion targeted for July 31, 2030, will fund investigations into how the local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a project grant of $151,040 under the Cancer Research Manpower program (CFDA 93.398) effective January 1, 2026, with completion scheduled for July 31, 2028. The award supports a research initiative titled "Toward Understanding the Functional Landscape of Proteolysis at the Cell Surface," which aims to develop advanced analytical methods and chemical...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center, effective May 1, 2026 through April 30, 2031, under the Cancer Biology Research program (CFDA 93.396). This research grant funds a five-year investigative study entitled "Control of T-Cell Stemness and T-Cell Exhaustion by KEAP1-NRF2 Axis," which will be conducted at the institution's Dallas, Texas campus. The research...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $648,626 to the University of California, Irvine, effective April 2, 2026, through March 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This award supports research investigating the mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy (CBI), specifically how programmed death receptor 1 (PD-1) blockade affects tumor microenvironments. The research seeks to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $658,722 to the University of California, San Francisco (UCSF) under the Cancer Treatment Research program (CFDA 93.395) beginning March 12, 2026 and extending through February 28, 2031. The project, titled "The Enabler of Tumor Cell Immortality in TERT Promoter Mutant Cancers," focuses on elucidating the molecular mechanisms by which telomerase reverse transcriptase (TERT) promoter mutations...
This Project Grant, awarded July 3, 2026, by the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) provides $237,546 in federal funding to The Regents of the University of California, San Francisco to support cancer research training and workforce development. The award funds a five-year project (through June 30, 2031) focused on biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research aligned with the National Cancer Program. The specific research initiative targets T cell exhaustion in cancer immunotherapy by combining mechanistic studies of TOX-dependent regulatory networks with synthetic biology approaches. The project delivers: (1) scientific dissection of how transcription factor TOX enforces exhaustion states in T cells through chromatin profiling and CRISPR-based perturbation studies in murine tumor models; and (2) development of programmable synthetic transcription factors designed to reprogram exhausted T cells and restore durable effector function. This research training and development effort supports the National Cancer Program's objectives by advancing understanding of fundamental barriers to effective cancer immunotherapy, particularly in solid tumors, and by training researchers in cutting-edge mechanistic and synthetic biology methodologies applicable to cancer immunology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $237.5k | 7/3/26 |