Project Grant K08CA308855
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under its Cancer Research Manpower program (CFDA 93.398), awarded $162,305.00 to the University of Michigan to support mentored research career development in cancer biology. Awarded on August 1, 2025, with a project period extending through July 31, 2030, this grant funds a K08 mentored research career development award for Dr. Peggy Hsu, MD, PhD. The project supports comprehensive investigation into early-stage Anaplastic...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $136,412 to the Regents of the University of Michigan, effective August 1, 2025 through July 31, 2027, under the Cancer Research Manpower program (CFDA 93.398). This award funds research aimed at defining and interrupting metabolic crosstalk in the glioblastoma microenvironment. The research builds upon preliminary findings demonstrating that glioblastoma (GBM) tumors acquire nutrients through...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $293,430 to the University of Michigan's Office of Research and Sponsored Projects on June 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support a five-year research initiative examining regional cancer care delivery optimization. The project, led by a colorectal surgeon and health services researcher, will leverage Michigan's Collaborative Quality Initiatives (CQIs) as a learning laboratory to...
- Federal Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $544,868 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective June 1, 2026, through May 31, 2031. The award supports research investigating SLC13A3 and its role in tumor resistance to immunotherapy, with a focus on understanding how the itaconate-SLC13A3 metabolic axis suppresses major histocompatibility...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $669,278 to the University of Michigan's Office of Research and Sponsored Projects, effective June 1, 2026 through May 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This Multi-Principal Investigator (MPI) R01 application, aligned with PAR-25-107 (Advancing Microbial-Based Cancer Therapy), supports the development of engineered nonpathogenic tumor-tropic E. coli bacteria...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan a $646,881 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026 through March 31, 2031. The research focuses on developing first-in-class small molecule inhibitors targeting ASH1L (Absent, Small or Homeotic 1-Like), a histone methyltransferase protein implicated in acute leukemia pathogenesis. The project addresses the urgent...
- Federal Grant Award Summary The National Cancer Institute awarded $2.82 million to the Regents of the University of Michigan under the Cancer Treatment Research program (CFDA 93.395) on August 6, 2025, with completion targeted for July 31, 2029. This Project Grant supports the development of new methods to measure metabolic pathway activity in glioblastomas (GBMs), deadly brain cancers that rewire their metabolism to enable growth, invasion, and treatment resistance. The research deliverables...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $147,083 to Icahn School of Medicine at Mount Sinai on August 1, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and workforce development in cancer research. The grant, which extends through June 30, 2026, funds a postdoctoral research project titled "Deconstructing Pathogenic Myelopoiesis in Cancer Immunosuppression and Treatment Resistance." This...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $214,993 under the Cancer Research Manpower program (CFDA 93.398) to support cancer research training and workforce development. The award, effective August 14, 2025, with completion targeted for February 29, 2028, funds biomedical training opportunities for individuals pursuing careers in basic and clinical research aligned with the National Cancer Program. This...
- Federal Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $610,498 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) on August 1, 2025, with a completion date of July 31, 2030. This award funds a comprehensive training initiative designed to build nationwide investigator capacity in adaptive intervention methodology for cancer control. The project will deliver didactic...
The National Cancer Institute awards $297,458 in Project Grant funding under the Cancer Research Manpower program (CFDA 93.398) to the University of Michigan's Office of Research and Sponsored Projects, effective September 1, 2026, through August 31, 2031. This K08 career development award supports Dr. Ameer Elaimy's research training and professional development in cancer metabolism, with the primary deliverable being an independent research program investigating hepatocellular carcinoma (HCC) treatment resistance. The award funds Dr. Elaimy's expansion of expertise across cancer biology, metabolism, redox biology, regulated cell death, advanced mouse modeling of HCC, and translational oncology under the mentorship of Dr. Theodore S. Lawrence and co-mentors Dr. Yatrik Shah and Dr. Daniel Wahl. The core research products under this award include investigations into how metabolic adaptation—specifically ammonia metabolism and its incorporation into glutathione biosynthesis—impacts tumor response to radiation therapy and immune checkpoint inhibition (ICI). The project will generate translational knowledge applicable to improving treatment outcomes for advanced HCC patients, particularly those with cirrhosis and impaired liver function who face elevated toxicity risks from conventional therapies. Deliverables include research findings, manuscript publications, and development of new therapeutic strategies addressing therapy resistance in gastrointestinal cancers through targeted metabolic intervention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $297.5k | 6/3/26 |