Project Grant K08CA293277
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $658,033 Project Grant to the University of Pennsylvania effective June 1, 2026, through May 31, 2031, under the Cancer Cause and Prevention Research program (CFDA 93.393). This project addresses pancreatic ductal adenocarcinoma (PDAC) through cancer interception strategies designed to eliminate premalignant lesions before progression to invasive cancer. The research focuses on translatable approaches to...
- The National Cancer Institute awarded MD Anderson Cancer Center a $141,195 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on May 15, 2026, with completion targeted for April 30, 2028. This K99/R00 mentored research award supports biomedical training and cancer research workforce development focused on elucidating how tumor suppressor gene (TSG) deficiencies—specifically CDKN2A and SMAD4 alterations—modulate pancreatic ductal adenocarcinoma (PDAC) response to oncogenic...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $191,700 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. This award supports research investigating the etiology and tumor characteristics of early-onset pancreatic cancer. The project delivers two primary research products: (1) epidemiological analysis identifying modifiable risk factors associated with...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded $188,080 to Massachusetts General Hospital's Research Management Division on August 22, 2025, for a two-year project extending through August 21, 2027. The award supports a mixed-methods research initiative titled "Enhancing Access in Pancreatic Cancer: Examining Facilitators and Barriers to Tertiary Referral for Complex Oncologic Surgical Care."...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $120,403 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective June 1, 2026 through May 31, 2027. The grant supports research development focused on pancreatic ductal adenocarcinoma (PDAC) detection and patient stratification for surgical intervention. The project employs ultrasensitive maximum depth sequencing (MDS) technology to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $109,080 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 1, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support a Phase II investigator-initiated, multicenter randomized controlled trial (RCT) evaluating predictive markers of response to a novel immunotherapeutic approach in treatment-naive metastatic pancreatic adenocarcinoma (MPDA). The...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $100,228 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cancer Research Manpower program (CFDA 93.398), with an award date of December 1, 2026, and a completion date of May 31, 2028. This grant supports research to identify and characterize fate determinants of basal-squamous pancreatic cancer, a particularly aggressive subtype associated with...
- Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Dr. David Bayne at the University of California, San Francisco a K23 career development grant of $369,889 (awarded September 15, 2025; completion June 30, 2030) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This award supports Dr. Bayne's research to develop and evaluate an intervention aimed at reducing loss to follow-up (LTFU) in urinary stone...
- Summary The University of Florida, in partnership with AdventHealth through a cooperative agreement with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is conducting clinical research to complete recruitment and long-term follow-up of patients with acute, relapsing acute, and chronic pancreatitis as part of the Chronic Pancreatitis Clinical Research Consortium (CPCRC)....
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $123,823 to the University of Maryland, Baltimore under the Cancer Research Manpower program (CFDA 93.398) effective June 1, 2026, through May 31, 2028. The project, titled "Transcriptomic, Genomic, and Microenvironmental Heterogeneity in Pancreatic Precancer: Subtyping, Classification, and Cross-Comparison," supports research and training initiatives focused on characterizing the molecular mechanisms...
OPTIMIZING SURGICAL DECISION-MAKING FOR PREMALIGNANT PANCREATIC CYSTS - PROJECT SUMMARY AND ABSTRACT PANCREATIC CYSTS ARE COMMON LESIONS THAT ARE FREQUENTLY DETECTED INCIDENTALLY ON IMAGING SCANS. INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS (IPMNS), THE MOST COMMON OF THESE LESIONS, HAVE THE POTENTIAL TO HARBOR CANCER OR DEVELOP INTO CANCER OVER TIME. TREATMENT OPTIONS INCLUDE EITHER A HIGH-RISK OPERATION OR ACTIVE SURVEILLANCE, WHICH RISKS LEAVING A POTENTIALLY CURABLE CANCER UNTREATED. THE DECISION BETWEEN SURGERY AND SURVEILLANCE REQUIRES KNOWLEDGE ABOUT THE RISK OF CANCER IN THE LESION, THE RISK OF SURGERY REQUIRED TO REMOVE IT, AND A PATIENT'S INDIVIDUAL PREFERENCES REGARDING VARIOUS POSSIBILITIES, SUCH AS LEAVING A POTENTIAL CANCER UNTREATED OR UNDERGOING AN UNNECESSARY SURGERY. IN PRACTICE, THIS TREATMENT DECISION CURRENTLY RELIES ON CANCER RISK ESTIMATES THAT ARE FLAWED BECAUSE OF BIASED SAMPLES AND RECOMMENDATIONS FROM TREATMENT CONSENSUS GUIDELINES THAT DO NOT INCORPORATE PATIENTS' PREFERENCES. THIS K08 PROPOSAL WILL ADDRESS THE FOLLOWING THREE SPECIFIC AIMS: AIM 1: QUANTIFY INDIVIDUALIZED RISK OF CANCER IN IPMNS; AIM 2: ELICIT PATIENTS' PREFERENCES TO INFORM DECISIONS ABOUT SURGERY VERSUS SURVEILLANCE FOR IPMNS; AIM 3: DEVELOP A DECISION MODEL FOR CHOOSING BETWEEN SURGERY AND SURVEILLANCE FOR IPMNS. THIS STUDY IS INNOVATIVE IN ITS REDUCING BIAS IN ESTIMATES OF CANCER RISK FOR PATIENTS WITH IPMN; ITS ELICITATION OF PATIENT PREFERENCES FOR PATIENTS WITH PRECANCEROUS LESIONS; ITS APPLICATION OF A MODELING APPROACH TO INDIVIDUALIZED DECISION MAKING; AND ITS DEVELOPMENT OF A DECISION ANALYTIC MODEL THAT CAN BE TAILORED TO PATIENTS' RISK THRESHOLDS. OUR FINDINGS WILL INFORM A SUBSEQUENT R01 TO EVALUATE THE EFFECTS OF A PRESCRIPTIVE DECISION MODEL ON TREATMENT DECISIONS AND OUTCOMES. THE CANDIDATE IS A SURGICAL ONCOLOGIST WITH EDUCATION AND EXPERIENCE IN HEALTH POLICY AND HEALTH SERVICES RESEARCH WHOSE LONG- TERM GOAL IS TO IMPROVE THE QUALITY OF SURGICAL DECISIONS, PARTICULARLY FOR TREATMENT OF THE MANY PREMALIGNANT LESIONS THAT ARE IDENTIFIED INCIDENTALLY. THE SPECIFIC OBJECTIVES OF THIS CAREER DEVELOPMENT AWARD ARE TO (1) OBTAIN TRAINING IN RISK PREDICTION METHODS USING REAL WORLD DATA; (2) ACQUIRE EXPERTISE IN PREFERENCE ELICITATION AND SHARED DECISION MAKING; AND (3) BUILD EXPERTISE IN DECISION MODELING. THIS K08 AWARD WOULD POSITION THE CANDIDATE TO BECOME A LEADER IN RESEARCH TO IMPROVE SURGICAL DECISION-MAKING.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $217.3k | 3/24/26 | ||
| Not listed | $299.2k | 7/30/25 | ||
| Not listed | $299.2k | 7/30/25 |