Project Grant K08CA279927

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $289K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
Memphis, TN 38105, USA
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  1. Conduct a Phase I clinical trial (MEMCAR19; NCT04881240) evaluating an allogeneic CD19-CAR T-cell product using donor memory T-cells to minimize the risk of graft-versus-host-disease (Aim 1).
  2. Perform intensive correlative studies to assess the in vivo characteristics of the CAR T-cells and further the understanding of CAR T-cell biology (Aim 2).
  3. Develop a new clinical trial evaluating a novel CAR T-cell product with dual-antigen targeting (CD19/22) and enhanced persistence through epigenetic modifications (DNMT3A knockout) (Aim 3).

The awardee, St. Jude Children's Research Hospital Inc., is a prominent nonprofit pediatric treatment and research facility in Memphis, Tennessee, known for its innovative research and dedication to advancing treatment protocols for childhood cancers and other life-threatening disorders.

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