Project Grant R21CA292221

Award Date 9/1/24
Completion Date 8/31/26
Dollars Obligated $503K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98101, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $503,194 to Seattle Children's Hospital (doing business as Seattle Children's Research Institute) to assess the efficacy of a multispecific T cell engager (MTE) therapy in treating neuroblastoma.

The key products/services to be delivered under this 2-year award (9/1/2024 - 8/31/2026) include:

  1. Determining the vulnerability of patient-derived neuroblastoma samples to the MTE therapy, which targets both ROR1 and PD-L1 to address resistance mechanisms.
  2. Evaluating the MTE's efficacy in pediatric tumors that are heterogeneous for ROR1 expression.

This innovative research aims to rapidly advance the MTE therapy to human clinical trials for children with neuroblastoma and other pediatric solid tumors, addressing an urgent need for new treatment options.

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