Project Grant K08CA277014
- This $194,022 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to facilitate the transition of the candidate, an oncologist at the Massachusetts General Hospital (MGH), to independence as a translational oncologist using deep learning (DL) to study therapeutic resistance in solid tumor oncology. The award will support the...
- This federal Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) provides $137,322 to Trustees of Boston University to develop disulfated polyamidosaccharide nanoparticles as a P-selectin targeting chemotherapeutic delivery system. The project aims to investigate the use of these nanoparticles to target and deliver cancer treatments to breast and lung cancer cells, which often exhibit high expression of the P-selectin protein. The award...
- This $128,228 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) is for the development of inhalable extracellular vesicles engineered to deliver interleukin-12 (IL-12) mRNA for lung cancer treatment. The primary goals are to enhance IL-12-based lung cancer immunotherapy by improving exosome-based mRNA delivery, and to investigate the potential role of cardiac fibroblast-derived exosomes in exacerbating lung cancer. The project aims to create more...
- This $400,000 Project Grant award from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) aims to develop a novel platform for delivering RNA-based therapeutics to gastrointestinal cancers. The project led by Accure Health Inc. will leverage artificial intelligence to design and engineer specialized membrane vesicles derived from the cyanobacterium Spirulina. These programmable vesicles are intended to enable targeted delivery of RNA-based cancer therapies, such as...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $448,250.00 to The Research Foundation For The State University Of New York (operating as Upstate Medical Center) to develop sulfonium lipid nanoparticles as a novel platform for mRNA delivery. The key objectives of this project are to: 1) expand the chemical diversity of sulfonium lipids by incorporating novel...
- The National Cancer Institute (NCI) has awarded a $154,400 Project Grant (CFDA 93.396 Cancer Biology Research) to The Broad Institute, Inc. to support research on activating the SLFN12 RNase enzyme's cytotoxic effects against cancer cells. The research aims to determine whether SLFN12 dimerization can induce tRNA-Leu-TAA degradation and cancer cell death, independent of the PDE3A protein. Experiments will test if high SLFN12 expression alone can trigger this cytotoxic response, and whether a...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $169,884 to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate the USP2-POU2F3 signaling pathway as a potential therapeutic target for small cell lung cancer (SCLC). The funded research aims to elucidate the molecular mechanisms regulating the POU2F3 oncoprotein, a key driver of the SCLC-P subtype, with the goal of identifying strategies to degrade POU2F3 and...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $635,248 to Trustees of Boston University to develop a novel self-amplifying ribonucleic acid (SARNA) technology encoding a bispecific T cell engager (BITE) antibody for the treatment of lung cancer. The key goals are to: Design 5-methylcytidine (5MC) modified SARNA constructs encoding BITE antibodies and evaluate their protein expression performance in vitro. Assess the in vitro and in...
- This $1,480,500 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to elucidate the cell intrinsic and extrinsic mechanisms underlying small cell lung cancer (SCLC) metastasis. The project will develop cutting-edge technologies to establish a comprehensive, spatiotemporally-resolved lineage tracing platform capable of recording the entire course of SCLC metastasis. Specifically, the...
- The University of California, Davis was awarded a $615,399 project grant from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) to develop a "transformable nanoparticle (TNP) platform" capable of modulating the tumor microenvironment on-demand using therapeutic peptides and proteins. The goal is to leverage the TNP platform's ability to preferentially accumulate at tumor sites and selectively deliver immunomodulatory payloads to stimulate an anti-tumor...
INVESTIGATING SLC46A3 AS A NEGATIVE REGULATOR OF NANOPARTICLE DRUG DELIVERY - PROJECT SUMMARY NANOPARTICLE-BASED THERAPIES HAVE MANY POTENTIAL ADVANTAGES FOR TREATING CANCER, BUT THERE ARE CURRENTLY NO CLINICAL BIOMARKERS TO PREDICT WHICH PATIENTS ARE MOST LIKELY TO BENEFIT FROM NANOTHERAPEUTICS OVER CONVENTIONAL ANTICANCER AGENTS. TO IMPROVE THE EFFICACY OF NANOPARTICLES FOR CANCER TREATMENT, I WILL INVESTIGATE NANOPARTICLE DRUG DELIVERY IN THE CONTEXT OF SLC46A3, A LIPOSOME-SPECIFIC BIOMARKER RECENTLY IDENTIFIED IN A MASSIVELY PARALLEL POOLED CANCER CELL LINE SCREEN. BASED ON STRONG PRELIMINARY DATA, I HYPOTHESIZE THAT SLC46A3 PLAYS A ROLE IN PHOSPHOLIPID METABOLISM IN CANCER CELLS, MAKING IT A THERAPEUTICALLY RELEVANT BIOMARKER FOR LIPOSOMAL NANOTHERAPEUTICS. THIS PROPOSAL AIMS TO ESTABLISH THE ROLE OF SLC46A3 IN PHOSPHOLIPID HOMEOSTASIS AND DIRECTLY CONNECT SLC46A3 EXPRESSION TO THERAPEUTIC LIPOSOME DELIVERY IN VIVO USING PEDIATRIC NEUROBLASTOMA AS A MODEL SYSTEM. THE ULTIMATE GOAL OF THE PROJECT IS TO VALIDATE SLC46A3 AS A CLINICAL BIOMARKER FOR LIPOSOMAL NANOPARTICLE DELIVERY AND DEVELOP RIGOROUS PRECLINICAL DATA TO MOTIVATE BIOMARKER-STRATIFIED CLINICAL TRIALS FOR BOTH EXISTING, FDA- APPROVED LIPOSOMES AND EXPERIMENTAL FORMULATIONS. I AM A PEDIATRIC ONCOLOGIST SEEKING K08 SUPPORT FOR A MENTORED TRAINING PERIOD UNDER THE CO-MENTORSHIP OF DR. PAULA HAMMOND AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT) AND DR. KIMBERLY STEGMAIER AT DANA-FARBER CANCER INSTITUTE/BOSTON CHILDREN'S HOSPITAL (DFCI/BCH). MY LONG-TERM CAREER GOAL IS TO BE AN INDEPENDENT PHYSICIAN-SCIENTIST, STUDYING NANO-BIO INTERFACES AND INTERACTIONS WITH THE GOAL OF ADVANCING NANOMEDICINE TO THE CLINIC FOR CANCER PATIENTS. MY PRIOR RESEARCH EXPERIENCES HAVE ESTABLISHED MY SKILLS IN NANOMEDICINE AND DRUG DELIVERY. I AM NOW WELL POSITIONED TO ESTABLISH THE NECESSARY EXPERTISE IN CANCER METABOLISM AND FUNCTIONAL GENOMICS THROUGH THE CRITICAL MENTORED K08 AWARD. THE DFCI/BCH, MIT AND THE BROAD INSTITUTE OF MIT AND HARVARD ARE INTERNATIONALLY RECOGNIZED RESEARCH PROGRAMS WITH A NUMBER OF EXPERT RESEARCHERS IN THE AREAS OF FUNCTIONAL GENOMICS, METABOLISM AND NANOMATERIALS, AMONG OTHERS. THE DFCI DIVISION OF PEDIATRIC ONCOLOGY HAS A DISTINGUISHED RECORD OF TRAINING YOUNG PHYSICIAN-SCIENTISTS FOR LEADERSHIP ROLES IN PEDIATRIC CANCER RESEARCH. I HAVE ASSEMBLED AN EXCELLENT MENTORING AND ADVISORY COMMITTEE, CONSISTING OF DR. MATTHEW VANDER HEIDEN (MIT), DR. ANGELA KOEHLER (MIT), AND DR. STEVEN DUBOIS (DFCI), WHO WILL GUIDE MY RESEARCH AND TRAINING EXPERIENCES ALONG WITH MY MENTORS. WITH STRUCTURED MENTORING, EDUCATIONAL, AND SCIENTIFIC PLANS, I WILL ACQUIRE THE NECESSARY EXPERTISE TO BECOME A SUCCESSFUL INDEPENDENT INVESTIGATOR IN TRANSLATIONAL CANCER NANOMEDICINE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $230.9k | 8/22/25 | ||
| Not listed | $1 | 6/12/25 | ||
| Not listed | $1 | 6/12/25 | ||
| Not listed | ($1) | 6/12/25 | ||
| Not listed | ($1) | 6/12/25 |