The Project Grant award of $1,175,680, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to comparatively assess the therapeutic potential of combined anabolic therapy versus the current standard-of-care single-drug approach in postmenopausal women at high risk of fragility fracture. Specifically, the study will test the hypothesis that in...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $158,912 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant will fund research to elucidate the function of Wnt signaling in the mechanical maturation of tendons and investigate if mechanical cues regulate Wnt signaling during this critical phase of...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under pathological inflammatory conditions. The research aims to elucidate how inflammation, particularly in the context of orthopedic periprosthetic...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $317,211 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to identify molecular and cellular mechanisms controlling tendon cell activation and regeneration after enthesis (tendon-bone attachment) injury. The award will fund a comprehensive...
This federal Project Grant award, valued at $783,176.00 and issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop and clinically validate a comprehensive bone quality assessment technique using photon-counting detector CT (PCD-CT) imaging. The research project, titled "Comprehensive Assessment of Bone Quality Using Clinical Photon-Counting Detector...
This $313,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research by Emory University to establish phosphorylated WNT5A produced by osteoclasts as a potential anabolic bone drug. The research aims to determine how osteoclast-derived phospho-WNT5A can enhance bone formation in vivo and elucidate the cellular and molecular mechanisms by...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will provide $652,729 to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan to investigate the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The research aims to define how loss of KDM5C affects osteoclast function,...
This Project Grant award, valued at $483,070.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research to investigate the dynamic mechanisms of bone extracellular matrix (ECM) assembly and resorption, and how these processes are integrated with osteogenic cellular dynamics and differentiation. Key aims include using advanced live-cell...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $359,133 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to generate new genetic tools for advancing tendon and musculoskeletal research. The project aims to develop constitutive and inducible Flippase (FLP) alleles that can be used with existing Cre/CreERT2 lines for...
This Project Grant award in the amount of $375,100.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will fund a two-year research study at the Regents of the University of Minnesota focused on identifying myeloid progenitors that help maintain cortical bone with age, and characterizing cells and molecules that promote coupling within cortical...