This Project Grant award, totaling $864,735, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of this research project is to identify novel mechanisms for generating antiretroviral antibody responses, with a focus on characterizing an alternative, Toll-like Receptor 7 (TLR7)-independent pathway for producing retrovirus-neutralizing antibodies. The University of Pittsburgh, a...
This $2,647,283 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to advance understanding of the role of B cells in immune responses and transplant rejection. The primary objectives are to: Further define the transcriptome and regulatory pathways of pro-inflammatory effector B cells (BEff) marked by the TIM-4 receptor, including how they counter-regulate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $183,701 to the University of Pittsburgh to identify post-translationally modified antigens using genetic code expansion. The goal is to build upon the university's previous work in developing a cell-based T cell antigen discovery approach called SABRS to identify post-translational modification (PTM) epitopes,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $373,359 to support a Physician Scientist Training Program in Immune Dysregulation at the University of Pennsylvania. The program will train 4 physician-scientist postdoctoral fellows to conduct research at the intersection of normal and pathological immune function, with the goal of elucidating the root causes of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,348 to support research into CD1a-restricted T cells that recognize the lipid antigen phosphatidylglycerol (PG). The research aims to investigate the conditions under which mitochondrial PG becomes visible to these T cells, as well as compare the antigenicity of mammalian versus bacterial PG. Single-cell...
This federal Project Grant award of $468,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a research project entitled "Spatial and Temporal Resolution of Eosinophil Specialization in Allergic Microenvironments". The project aims to elucidate the regulation and function of tissue-resident eosinophils, which play a key role in allergic and inflammatory diseases. The research...
This Project Grant award, valued at $187,398, was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the role of Programmed Death Ligand-1 (PD-L1) and CD80 in regulating dendritic cell migration and T cell priming. Specifically, the research aims to: 1) Define the extracellular interactions between PD-L1 and CD80 that govern dendritic cell migration, and...
This Project Grant award in the amount of $612,975.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of the research project is to develop an approach that combines T cell costimulation blockade with inhibition of monocyte allorecognition via CD47 to induce long-term allograft acceptance without the need for chronic immunosuppression. The research will investigate the...
This federal Project Grant award of $451,292.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to uncover the neuronal mechanisms orchestrating metabolic adaptations to bacterial infections, specifically delineating the pivotal role of the brain-liver axis in modulating host metabolic responses. The research proposal seeks to identify neurocircuits in the hypothalamus that monitor circulating...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,245,701 to the University of Pittsburgh to support research on mechanisms of allergen-induced tolerance in the lung. The primary objectives are to: 1) Dissect the impact of dendritic cell-specific deletion of the MARCKSL1 gene on loss of allergen tolerance, 2) Determine the role of mitochondrial reactive...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $189,540.00 to the University of Pittsburgh to investigate the role of apolipoprotein E (ApoE) in regulating lymph node stromal cell function and lipid metabolism during autoimmunity. The research aims to determine how ApoE inhibits the suppressive capacity of T cell zone fibroblastic reticular cells (TRCs) and affects lipid metabolism in TRCs and T cells. The outcomes are expected to define the role of ApoE in TRCs, reveal mechanisms driving TRC regulation of T cell activation, and establish a potential mechanistic link between lipid metabolism and immune regulation. This 5-year award, commencing on April 18, 2025, will support the career development of the principal investigator, Dr. Poholek, an MD/PhD trained pediatric rheumatologist and basic immunologist, as they build expertise in lipid metabolism and advanced microscopy to establish an independent research program focused on lipid metabolism and autoimmunity.