The University of Pittsburgh received a $1,125,259 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will fund research to investigate the mechanisms of allergen-induced tolerance in the lung, with the goal of developing new approaches to prevent and treat allergic diseases like asthma.
Specifically, the research will examine how repeated exposure to low doses of house dust mite allergen can program lung dendritic cells to induce long-term tolerance, potentially suppressing the development of tissue-resident memory T cells that drive allergic inflammation. The project aims to dissect the role of the protein MARCKSL1 and mitochondrial reactive oxygen species in this tolerance induction process. The findings could inform the development of novel allergen immunotherapy strategies to provide long-term protection against allergic diseases.
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