This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,127,548 to the University of Texas Medical Branch at Galveston to investigate the role of post-translational modifications of myosin and its chaperone UNC-45 in the development of sarcopenia, the age-related loss of muscle mass and function. The project aims to use a combination of in vitro biochemical and biophysical assays, as well as in vivo techniques in the C. elegans model organism,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) provides $1,130,661.00 to the Regents of the University of Michigan to conduct research on the cellular and molecular mechanisms underlying motor unit expansion, a compensatory process that preserves muscle function during aging and neurodegenerative conditions like amyotrophic lateral sclerosis (ALS). The project aims to: (I) characterize how Schwann cell populations and their signaling...
This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,512 to the University of Florida to conduct research on the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and muscle weakness. The 16-month project will use novel genetic mouse models to investigate whether elevated kynurenine levels and increased AhR activity in skeletal muscle are mechanistic drivers of the decline in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This Project Grant awarded by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research supports research to explore the sex-specific determinants of muscle quality in older adults. The $116,710 award will fund a study at the University of Connecticut to directly measure muscle quality, neurological impairment, muscle adiposity, and muscle stiffness in 60 older adults, comparing 30 males and 30 females. The goal is to identify sex-specific therapeutic targets to improve muscle...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $1,294,013 to Mayo Clinic to conduct a randomized clinical trial examining the impact of biological mechanisms of aging on exercise response variability in older adults. The project aims to define the heterogeneity in physical function and insulin sensitivity outcomes in response to a 6-month resistance training intervention, with a focus on investigating the...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine whether altered sodium channel expression and gating underlie early age-related slowing of muscle conduction velocity. The research will analyze muscle samples from standard and accelerated aging mouse models, and will also assess whether caloric restriction can delay age-related changes in sodium channel function and expression. Insights from this work could help address declining muscle power in older populations and preserve mobility and quality of life.