This $143,949 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research aimed at defining how antibiotic-mediated gut dysbiosis and loss of certain short-chain fatty acid (SCFA)-producing bacteria alter intestinal and joint inflammatory responses. The 5-year project, led by Fang Roseanne Zhao, M.D., Ph.D. at Washington University, will use...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $412,610.00 to the Oklahoma Medical Research Foundation (OMRF) to investigate associations between the peripheral blood microbiome and knee osteoarthritis. The key objectives are to determine if baseline peripheral blood bacterial DNA patterns can predict future radiographic and...
This $627,000 Project Grant from the US Department of Agriculture National Institute of Food and Agriculture's Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) will fund research at the University of Illinois from May 1, 2023 to April 30, 2026. The research aims to identify early gene and protein expression changes after equine joint injuries to further understanding of post-traumatic osteoarthritis (PTOA) development. Twelve horses will undergo controlled fetlock chip...
This $499,659 federal Project Grant award from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) supports research conducted by Colorado State University to evaluate a novel sting intra-articular immunotherapy for treating post-traumatic osteoarthritis in an ovine (sheep) knee model. The award, which runs from August 1, 2025 to July 31, 2027, aims to advance therapeutic approaches for a condition that affects military personnel and the broader public....
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $618,629 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado to establish a new "microphysiological joint-on-chip" system. The objective is to create a realistic human joint model that can support mechanistic study of arthritic diseases and rapid testing of candidate treatments. The researchers plan to develop...
The National Science Foundation awarded a two-year, $138,000 Project Grant to support research titled "Extremes in the Interplay: The Development and Effects of Gut Microorganisms within Earth's Largest Terrestrial Species." The grant was awarded on August 1, 2021 under the Biological Sciences program (CFDA 47.074) to be conducted in Fort Collins, Colorado through July 31, 2023. The $138k grant will fund research examining the gut microbiomes of large terrestrial species and how...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $456,808 to the Buck Institute for Research on Aging to develop innovative mass spectrometry imaging (MSI) technologies and perform deep proteomic profiling of bone tissues. The goal is to spatially visualize changes in the extracellular matrix and glycans related to osteoarthritis,...
The University of Kentucky Research Foundation was awarded a $458,907 Project Grant by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to determine if introducing gut microbiome from exercise-trained mice, specific probiotic bacteria, or microbial-derived metabolites can attenuate skeletal muscle atrophy due to disuse. The research aims to...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, operating as the University of Colorado, with a period of performance from July 4, 2024 to August 31, 2027. The funding will support the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance...
This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), provides $277,817 to Oklahoma State University (OSU) to conduct research on the potential role of gut microbiomes in facilitating organism adaptation to environmental changes, such as climate change. The key objectives of the project are to: (1) determine the effect of gut microbiota on adult host phenotypes across environmental gradients, (2) investigate the relationships...