Project Grant K01MH137689

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $185K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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This federal Project Grant award of $185,220, provided by the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants, will support research to characterize the behavioral, neural, and inflammatory measures of response inhibition in patients with bipolar disorder. The key products and services to be delivered include:

  1. Characterizing response inhibition using self-report and performance-based measures in 100 patients with bipolar disorder and 50 healthy controls.
  2. Assessing the neural circuitry underlying response inhibition through brain activation patterns and resting-state functional connectivity analysis.
  3. Examining the association between peripheral inflammation, central inflammation, and the behavioral and circuit-based processes underlying response inhibition.

The research will be conducted at Brigham and Women's Hospital, which is a subsidiary of the larger Partners Healthcare System Incorporated organization. This project aims to identify biobehavioral mechanisms that can inform the development of interventions to reduce impulsivity and related risky behaviors in patients with bipolar disorder.

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