This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $811,404 to The Trustees of Columbia University in the City of New York to conduct research on the neural circuitry underlying anticipatory anhedonia in schizophrenia. The research aims to utilize a computational psychiatry approach to dissect the neural mechanisms of altered reward anticipation, which may serve as novel targets for treating...
This federal Project Grant award of $2,210,865, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to identify unique neural and inflammatory mechanisms of depression in people living with HIV (PLWH). The University of California, Los Angeles (UCLA) will conduct a cross-sectional study to enroll PLWH who are depressed and non-depressed, as well as HIV-negative subjects who are depressed and non-depressed. The research...
The National Institute of Mental Health (NIMH) awarded a $514,178 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Laureate Institute For Brain Research, LLC, a non-profit research organization in Tulsa, Oklahoma. The award will fund a 5-year research project to investigate the mechanistic relationship between brain circuit function and negative valence system behaviors, such as anhedonia and rumination, in individuals with treatment-resistant depression. The...
This federal Project Grant award of $734,220.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the impact of early life adversity on positive affect and its neural underpinnings. The University of Pittsburgh will conduct this research, which includes: Determining if there is a reduction in the behavioral persistence or intensity of positive affect for youth exposed to adversity. Examining if...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants, provides $738,037 to The Washington University to conduct research on predicting attenuated psychotic symptoms among youth who endorse persistent distressing psychotic-like experiences. The key objectives are to: 1) examine the prevalence of attenuated psychotic symptoms (APS) among youth in the Adolescent Brain Cognitive Development (ABCD) study sample, 2)...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program provides $1,088,500.00 to The Washington University in St. Louis to conduct research on the neural circuits and cytokine codes that govern behavioral responses to inflammation. The project aims to elucidate how the immune and central nervous systems communicate to regulate motivation and mood, with a focus on chronic inflammatory conditions...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants program, will fund a 3-year research study on the structural, functional, and neurobehavioral consequences of COVID-19 infection during adolescence. The $183,096 award will support the principal investigator at the University of Maryland, Baltimore in conducting longitudinal neuroimaging, cognitive, and psychiatric assessments to evaluate the impact of SARS-CoV-2...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants aims to investigate the developmental origins of mental illness by studying the structure and function of the human hypothalamus. The $392,500 award, effective January 1, 2025 through December 31, 2029, will capitalize on large-scale datasets from the Adolescent Brain Cognitive Development (ABCD) and Healthy Brain and Child Development (HBCD) studies to: 1)...
This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on understanding the neural mechanisms underlying psychiatric comorbidities across posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The $769,753 award will leverage large-scale multimodal neuroimaging datasets from ENIGMA and UK Biobank to identify neural biomarkers and biotypes that can help...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $233,250 to The Washington University to conduct research on the relationship between neuroinflammation and anhedonia, a symptom of mental health disorders. The project aims to utilize UK Biobank and Adolescent Brain Cognitive Development datasets, along with the innovative Diffusion Basis Spectrum Imaging technique, to investigate the cross-sectional and longitudinal associations between peripheral inflammation, regional neuroinflammation, and anhedonia symptoms. The findings are expected to provide novel insights into the etiology of anhedonia across mental disorders and potential age-specific patterns, which could inform future interventions and treatments. The award period runs from November 13, 2024 to October 31, 2026.