This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $500,500.00 to St. Jude Children's Research Hospital Inc. to study the LRRC57 gene and its role in neurotrophic growth factor signaling, synaptic function, and behavior related to bipolar disorder. The award period runs from August 1, 2024 to July 31, 2026. The project aims to elucidate the biochemical functions of LRRC57, identify its interacting protein partners, and determine the functional importance of those interactions. It will also investigate the role of LRRC57 in neural excitability, synaptic transmission, and long-term synaptic plasticity, particularly in neurotrophin-dependent forms of synaptic plasticity in the hippocampus. Cognitive function and bipolar disorder-related behaviors in mice with conditionally deleted or overexpressed LRRC57 will also be tested. This research is expected to provide foundational understanding of the previously unrecognized, evolutionarily conserved LRRC57 gene and its potential involvement in bipolar disorder.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $500.5k | 7/30/24 |