The University of Pittsburgh was awarded a $705,915 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct the "Integrative Model of Metabolomics, Equol and Atherosclerotic Cardiovascular Disease (IMMEA)" study. The study aims to (1) determine the association of equol-producing status with atherosclerotic cardiovascular disease (ASCVD) and (2) build predictive models of ASCVD from equol, marine omega-3 fatty acids,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research supports research to investigate the role of the serine-threonine kinase, serum glucocorticoid kinase 1 (SGK1), in cardiometabolic heart failure with preserved ejection fraction (CMET HFPEF). The $732,779 award to the University of Utah aims to: (1) determine the role of cardiac-specific SGK1 in regulating heart function, metabolism, and inter-organ...
This Project Grant award of $194,400 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a multilevel implementation intervention to equitably prescribe evidence-based therapy for hospitalized heart failure patients. The key products or services to be delivered through this funding include: Assessing multilevel variation in equitable guideline-directed medical therapy (GDMT) prescribing during...
This $132,410 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will provide protected time for Dr. Cheryl Anderson, a mid-career clinical investigator, to recruit and mentor a diverse group of trainees in clinical cardiovascular epidemiology and health equity research. The award will support two new areas of research: 1) integrating global policy and strategy into multilevel interventions to improve...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
This federal Project Grant award under the National Heart Lung and Blood Institute's (NHLBI) Cardiovascular Diseases Research program (CFDA 93.837) provides $138,523 to Brigham & Women's Hospital Inc. to systematically compare the mechanisms involved in medial and intimal calcification subtypes, which are distinct drivers of age-related vascular disease and cardiovascular morbidity and mortality. The award, effective from July 2025 through May 2027, will use spatial and extracellular vesicle...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $234,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct secondary analysis of noninvasive imaging biomarkers for early prediction of single ventricle heart disease (SVD) failure. The project aims to noninvasively quantify systemic and pulmonary vascular compliance through...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA Program 93.837 - Cardiovascular Diseases Research aims to elucidate the mechanisms by which microbial metabolites mediate the impact of early life stress (ELS) on aortic stiffening and endothelial dysfunction, which are risk factors for cardiovascular disease (CVD). The $249,000 award to the University of Alabama at Birmingham will fund research to: 1) identify ELS-mediated factors that regulate the...
This federal Project Grant award of $671,986 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to strengthen the evidence-base for medication prescribing in older adults with chronic kidney disease (CKD). The primary objectives are to: 1) Evaluate the effectiveness of renoprotective therapies, such as angiotensin converting enzyme inhibitors (ACEIs) and sodium-glucose...